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Not yet recruiting NCT07070414

Substance Use in Assault-Injured Young Adults

No phase Interventional Alcohol Misuse Cannabis Misuse

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Brief Negotiation Interview intervention (BNI) (adapted).
Who it may be relevant to
Registry conditions: Alcohol Misuse, Cannabis Misuse. Basic parameters: 18 years — 25 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Alcohol and Cannabis Use Among Assault-Injured Emerging Adults

Overview

This study aims to improve a short motivational conversation to better help young adults who were injured in assaults and also use alcohol or cannabis. Researchers will gather both interview and survey data from young adults who came to the emergency department after an assault and currently use alcohol or cannabis. Guided by a theory about risky behaviors, the study will focus on how confident young people feel about making changes to their alcohol and cannabis use, and how their friends and family influence their alcohol and cannabis use and involvement in injuries from assault. The team will follow a step-by-step process used by the NIH to adapt and test the improved motivational conversation in the emergency department.

Detailed description

Aim 1: Quantitatively and qualitatively assess self-efficacy, perceived peer and familial norms, and motivation to reduce alcohol and/or cannabis use and engage in treatment referral, among assault-injured emerging adults. AIM 2: Adapt the BNI for use among assault-injured emerging adults with alcohol and/or cannabis misuse in the ED. AIM 3: Determine the feasibility and acceptability of an adapted BNI among assault-injured emerging adults with alcohol and/or cannabis misuse presenting to the ED through a randomized pilot trial comparing those who have received the adapted BNI and treatment referrals to a referrals-only control group. The focus of this registration is the randomized pilot in Aim 3. Anticipated start dates will be reflected in the clinical trial component in Aim 3.

Interventions

  • Behavioral Brief Negotiation Interview intervention (BNI) (adapted)
    A brief motivational interview designed to increase motivation to reduce alcohol and/or cannabis use and engagement in treatment referral.

Primary outcome measures

  • Feasibility assessed by recruitment [Time frame: Day 0 and 30]
  • Feasibility assessed by randomization [Time frame: Day 0 and 30]
  • Feasibility assessed by retention [Time frame: Day 0 and 30]
  • Acceptability assessed by Acceptability of Intervention Measure (AIM) [Time frame: Day 0]

Eligibility criteria

Inclusion criteria

Aim 1:

  • Be clients of the Yale Hospital Violence Intervention Program (YHVIP)
  • Be between the ages of 18-25 y/o upon study enrollment
  • Have sustained an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse in the past year
  • Report current alcohol and/or cannabis misuse
  • Be English-speaking and able to provide informed consent.

Aim 2 and 3:

  • Present to Yale New Haven Hospital ED for an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse
  • Be between the ages of 18-25 y/o upon study enrollment
  • Report current alcohol and/or cannabis misuse
  • Be English-speaking and able to provide informed consent.

Exclusion criteria

Aim 1:

  • Be actively suicidal or severely cognitively impaired precluding informed consent
  • Sustain an intentional injury from a boy/girlfriend, fiancée, or spouse or sexual assault
  • Be incarcerated or in police custody
  • Currently engaged in addiction treatment

Aim 2 and 3:

  • Be actively suicidal or severely cognitively impaired precluding informed consent
  • Sustain intentional injury from a boy/girlfriend, fiancée, spouse or by sexual assault
  • Be incarcerated or in police custody
  • Currently engaged in addiction treatment

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Prevention

Study locations

United States · 1 center
  • Yale Department of Emergency Medicine — New Haven

Publications

  • Coupet E Jr, Dodington J, D'Onofrio G, Stover CS, Dziura J, Vega CP, Couvertier E, Latham E, Gawel M, Fiellin DA, Fretz SL, Vaca FE. An adapted brief negotiation interview for alcohol and cannabis use among assault-injured emerging adults: A randomized pilot trial protocol. Contemp Clin Trials. 2026 May;164:108287. doi: 10.1016/j.cct.2026.108287. Epub 2026 Mar 14. PMID 41839387

Identifiers

NCT: NCT07070414 · 2000040490 · 1R34DA061051-01A1

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗