Recruiting NCT07069478
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Stress Intervention.
- Who it may be relevant to
- Registry conditions: CBD, Cannabidiol, Stress, Acute Stress Reaction. Basic parameters: 21 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
Interventions
- Other Stress Intervention
Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.
Primary outcome measures
- Change in subjective states (stress, anxiety, positive affect) [Time frame: 2.5 hours]
- Change in cardiovascular activity and cortisol [Time frame: 2.5 hours]
Eligibility criteria
Inclusion criteria
- Adults who are relatively healthy and aged 21-70 years.
- Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
- Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
Exclusion criteria
- Participated in previous acute stress studies that included a similar stress induction.
- Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
- Self-reported current pregnancy.
- Self-reported current use of illicit substances (other than cannabis).
- Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
- Students of the principal researcher
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Minnesota — Minneapolis
Identifiers
NCT: NCT07069478 · DMED-2025-33636