Regional Ventilation Evaluation During Neuro-injury Weaning Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Internal Thoracic Impedance.
- Who it may be relevant to
- Registry conditions: Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of Regional Ventilation in Neuro-injured Patients Undergoing Weaning From Mechanical Ventilation
Overview
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury. It aims to identify predictive EIT patterns related to extubation outcomes.
Detailed description
This is a prospective, single-center pilot study conducted in the intensive care unit. The study focuses on adult patients with acute brain injury requiring invasive mechanical ventilation for more than 48 hours. The aim is to assess regional alveolar ventilation using thoracic electrical impedance tomography (EIT) during different stages of ventilator weaning, including changes in ventilatory mode, spontaneous breathing trials, and, when feasible, around extubation or decannulation.
EIT provides dynamic, non-invasive real-time imaging of regional pulmonary ventilation. Data will be collected using a 16-electrode thoracic belt and analyzed retrospectively with dedicated software. The primary outcome measure is the Absolute Ventral-to-Dorsal Ventilation Difference, calculated from predefined regions of interest. Secondary outcomes include correlations with traditional ventilatory parameters (tidal volume, respiratory rate, oxygen saturation), end-expiratory impedance variation (ΔEELI), compliance changes, and extubation or decannulation failure defined by the need for reintubation within 7 days.
This study aims to improve understanding of regional ventilation patterns in brain-injured patients and assess the potential of EIT to predict weaning outcomes and guide personalized ventilatory strategies.
Interventions
- Other Internal Thoracic Impedance
Internal Thoracic Impedance is a non-invasive an imaging technique which use low alternative current through electrodes placed on a belt positioned at the level of the patient's rib cage. Images are constructed according to conductivity measured.
Primary outcome measures
- Absolute ventral-to-dorsal ventilation difference [Time frame: From the start of the ventilator mode change or spontaneous breathing trial until 30 minutes after.]
Secondary outcome measures (5)
- Correlation between Absolute V-D Difference and Conventional Ventilatory Parameters [Time frame: From the start of the ventilator mode change or spontaneous breathing trial until 30 minutes after]
- End-Expiratory Lung Impedance (ΔEELI) [Time frame: From 5 minutes before to 5 minutes after the 30-minute spontaneous breathing trial (i.e., total duration of 40 minutes)]
- Correlation between ΔEELI and Extubation/Decannulation Failure [Time frame: 7 days post-extubation or post-deventilation.]
- Pulmonary Compliance Variation during Ventilator Changes and Spontaneous Breathing Trials [Time frame: From the start of ventilator mode change or spontaneous breathing trial until 30 minutes after.]
- Absolute V-D Difference and Extubation Failure [Time frame: 7 days post-extubation or post-deventilation.]
Eligibility criteria
Inclusion criteria
- Age 18 or older
- Hospitalized in intensive care for an acute brain injury.
- Mechanical ventilation for more than 48 hours.
- Ventilator withdrawal planned in the next few days
- Social security coverage
Exclusion criteria
- Pregnancy
- Moribund patient / decision to stop treatment
- Patient under state medical aid
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Hôpital Lariboisière - APHP — Paris
Identifiers
NCT: NCT07067671 · APHP250700 · 2025-A01069-40