Effect of Vitamin D on Crestal Bone Loss Around Immediate Implant After Mandibular Premolars and Molars Extraction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: vit D mixed with xenograft, only xenograft without vit D.
- Who it may be relevant to
- Registry conditions: Crestal Bone Loss. Basic parameters: 20 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Clinical and Radiographic Assessment Of Immediate Implant With Topical Vitamin D and Xenograft Mixture: A Randomized Controlled Study
Overview
What is the difference between grafting the jumping gap upon using xenograft mixed with topical vitamin D clinically regarding crestal bone level and implant stability, radiographically regarding crestal bone level after implant insertion in the posterior region of mandible?
Detailed description
Effect of Vitamin D on Bone Regeneration .Vitamin D is known for its role in the skeletal system. Vit D deficiency is also widely researched for its effects on the healing of fractures, bone defects and osseointegration of implants. There are studies that investigated the effects of dietary supplementation with vitamin D to reduce vitamin D deficiency but increasing the serum level of this vitamin takes time therefore, an attempt has been made to combat the effect of vitamin D deficiency through topical application. up to the knowledge, upon search of literatures, there is not enough studies that correlate topical application of vitamin D with xenograft mixture as filling space material. this study is to Assess immediate implant with topical vitamin D and xenograft mixture clinically and Radiographically.
Interventions
- Drug vit D mixed with xenograft
Topical application of vitamin D solution mixed with xenograft in the jumping gap around immediate implant - Drug only xenograft without vit D
grafting the jumping gap with xenograft only around immediate implant
Primary outcome measures
- clinically: A)Loss of crestal bone. B)Stability of implant. Radiographically: crestal bone loss by periapical radiograph in millimeters. [Time frame: clinically: Loss of crestal bone by periodontal prop assessed in millimeters in six months Stability of implant by OSTTEL assessed as ISQ values in six months crestal bone loss in millimeters will be one ,three months and six months.]
Eligibility criteria
Inclusion criteria
- The American Society of Anesthesiologist (ASA) I , II
- Both Genders. 3- Patients having unrestorable tooth on the posterior mandibular region
- Age>20
- The patient who have complete their facial growth and teeth eruption
- No bone disease or lesion in propose implant site
Exclusion criteria
- Poor oral hygiene patients and/or patients
- Patients with active acute infection.
- Patients with bad oral habits.
- Pregnant or lactating women.
- Heavy smokers.
- Alcohol and drug addicts.
- Diabetes disease
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- oral and maxillofacial surgery depertment of oral and dental medicine faculty Suez canal u — Ismailia
Identifiers
NCT: NCT07065877 · 961/2025