Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: ambiant air, Oxygen, ambiant air.
- Who it may be relevant to
- Registry conditions: COPD. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Kyrgyzstan, Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in Patients With COPD
Overview
Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Interventions
- Other ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air - Other Oxygen
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training - Other ambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
Primary outcome measures
- 1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle [Time frame: baseline to 3 weeks]
Secondary outcome measures (3)
- Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation. [Time frame: baseline to 3 weeks]
- Change in ∆Xrs (Difference in Reactance) before and after rehabilitation [Time frame: baseline to 3 weeks]
- Change in Rrs, Xrs and ∆Xrs from low to moderate altitude [Time frame: From baseline at low altitude to transfer to moderate altitude at 3 days]
Eligibility criteria
Inclusion criteria
- Aged ≥18 years
- Stable clinical condition for >3 weeks (e.g., no exacerbations)
- Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
- Informed consent documented by signature
Exclusion criteria
- Severe daytime resting hypoxemia (SpO₂ <88%)
- Long-term oxygen therapy
- Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
- Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
- Women who are pregnant or breastfeeding
- Enrolment in another clinical trial involving active treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Sequential
- Masking
- Quadruple blind
- Primary purpose
- Treatment
Study locations
Kyrgyzstan · 1 center
- National center for cardiology and internal medicine — Bishkek
Switzerland · 1 center
- Eastern Switzerland University of Applied Sciences — Sankt Gallen
Identifiers
NCT: NCT07063563 · inRehaExO2_FOT