Prehabilitation in Ovarian Cancer Patients During Chemiotherapy Before Cytoreductive Surgery.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Prehabilitation. An intensive prehabilitation for NACT patients.
- Who it may be relevant to
- Registry conditions: Ovarian Cancer. Basic parameters: 18 years — 80 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
An Intense Course of Prehabilitation in Ovarian Cancer Patients During Neoadjuvant Treatment Awaiting for Interval Debulking Surgery. PREHONED - a Prospective, Randomized, Multicentre Clinical Study.
Overview
Prehabilitation includes care for patients preparing for surgery. This is a modern approach aimed at increasing the patient's functional capacity before surgery and improving postoperative results. Prehabilitation includes preoperative physical activity, nutritional intervention, psychological support, cessation of stimulants and optimization of laboratory test results. Many studies have shown a positive effect of prehabilitation on postoperative results, mainly reducing the number of postoperative complications and shortening the hospitalization time. The assumed time of prehabilitation is 2-6 weeks, but in the case of oncology patients, the procedure should not be delayed only for the sake of prehabilitation. Our study includes oncology patients with ovarian cancer who are referred for neoadjuvant chemotherapy before interval cytoreductive surgery. The assumption of the study is an intensive course of prehabilitation during neoadjuvant treatment, which should provide significantly better postoperative results.
Interventions
- Procedure Prehabilitation. An intensive prehabilitation for NACT patients
Patients referred to NACT (neoadjuvant chemotheraphy) for advanced ovarian cancer will undergo an intensive course of prehabilitation including physical exercise, a high-protein diet, protein and vitamin supplementation, optimization of laboratory test results, and psychological support will be provided.
Primary outcome measures
- Frequency of postoperative complications [Time frame: from surgery for the next 30 days]
- Length of hospital stay [Time frame: from surgery to hospital discharge (assessed up to 14 days)]
- Time to start adjuvant chemotherapy [Time frame: from discharge from hospital for the next 2 months]
Secondary outcome measures (2)
- Progression-free survival [Time frame: From the time of the operation for the next 3 and 5 years]
- Overall survival [Time frame: From the time of the operation for the next 3 and 5 years]
Eligibility criteria
Inclusion criteria
- Patients with confirmed ovarian cancer
- No possibility of performing primary debulking surgery (Fagotti score > 8 points). Referral patient for neoadjuvant chemotherapy
- Consent to participate in the study
- Age over 18 years
Exclusion criteria
- Performing primary debulking surgery
- Lack of consent to participate in the study
- Aletti score < 4 points in interval debulking surgery
- Severe neurological/psychiatric disorders that make contact with the patient difficult
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Poland · 1 center
- Department of Gynecology, Obstetrics and Gynecological Oncology, University Clinical Cente — Katowice
Identifiers
NCT: NCT07058753 · PREH/2025-2-1 · PREH/2025-2-1