Recruiting NCT07056582
Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dexmedetomidine, Ketamine, 0.9%sodium chloride.
- Who it may be relevant to
- Registry conditions: Nose Diseases. Basic parameters: 20 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
this study aims to compare the efficacy of pre-emptive nebulized ketamine versus nebulized dexmedetomidine for post operative pain relief in endoscopic nasal surgery
Interventions
- Drug Dexmedetomidine
patients in this group will receive nebulized Dexmedetomidine before onset of surgery - Drug Ketamine
patients in this group will receive nebulized ketamine before onset of surgery - Drug 0.9%sodium chloride
patients in this group will receive nebulized 0.9% normal saline before onset of surgery
Primary outcome measures
- This study aims to assess the efficacy of nebulized dexmedetomidine vs nebulized ketamine to achieve good postoperative pain management in patients undergoing endoscopic nasal surgeries. [Time frame: 24 hours after operation]
Eligibility criteria
Inclusion criteria
- patients between the ages of 20 and 60,
- both sexes,
- American Society of Anesthesiologists physical status I to II
- BMI ≥18≤30 kg/m²
Exclusion criteria
- Patient refusal.
- patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women.
- patients with a history of allergies to any study drugs.
- patients who had used central nervous system depressants or analgesics within the previous 24 hours.
- patients with hypertension, hypotension, or bradycardia.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Egypt · 1 center
- Sohag university hospital — Sohag
Publications
- Parthasarathy S, Krishnapriyanka KJ, Saravanan B. Effectiveness of pre-emptive nerve block on opioid consumption in patients undergoing nasal surgery under general anaesthesia: A double-blinded randomised controlled study. Indian J Anaesth. 2022 Feb;66(2):133-139. doi: 10.4103/ija.ija_813_21. Epub 2022 Feb 24. PMID 35359478
- Prasant NVSN, Mohapatro S, Jena J, Moda N. Comparison of Preoperative Nebulization with 4% Lignocaine and Ketamine in Reduction of Incidence of Postoperative Sore Throat. Anesth Essays Res. 2021 Jul-Sep;15(3):316-320. doi: 10.4103/aer.aer_105_21. Epub 2022 Feb 14. PMID 35320968
- Cai Y, Xu H, Yan J, Zhang L, Lu Y. Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury. Mol Med Rep. 2014 May;9(5):1542-50. doi: 10.3892/mmr.2014.2034. Epub 2014 Mar 10. PMID 24627001
Identifiers
NCT: NCT07056582 · Soh-Med--25-4-08MS