The Advancing Dynamic And Personalized Training Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Healthy Minds Program (HMP) app.
- Who it may be relevant to
- Registry conditions: Well-Being, Psychological. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This study aims to enhance the Healthy Minds Program (HMP) app by developing and testing a personalized, data-driven approach to optimize long-term well-being. 1100 participants will be enrolled and on study for up to 4 months (4 week intervention plus 3 month follow-up).
Detailed description
Participants will be randomly assigned to various training conditions that vary across six factors. Each of the six factors is binary ("yes" vs. "no"), and for each factor there is a 50 percent probability of assignment to either level.
1. Introduction video for the app (yes / no) 2. Introduction video for the training modules (yes / no) 3. Module order based on ACIP score (highest-first / lowest-first) 4. Practice-nudging text messages (yes / no) 5. Microsupport messages during the intervention period (yes / no) 6. Microsupport messages during the follow-up period (yes / no)
Participants will take surveys at baseline, weekly through the 4-week intervention, and 3-month follow-up.
Interventions
- Other Healthy Minds Program (HMP) app
All participants will complete baseline surveys, weekly questionnaires (for 4 weeks) through the HMP app intervention, and will be surveyed again at 3-months post-intervention. Participants are randomized to each of the following binary conditions. 1. Introduction video for the app (yes / no) 2. Introduction video for the training modules (yes / no) 3. Module order based on ACIP score (highest-first / lowest-first) 4. Practice-nudging text messages (yes / no) 5. Microsupport messages during the
Primary outcome measures
- Change in PHQ-9 [Time frame: Baseline, week 1, week 2, week 3, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
Secondary outcome measures (12)
- Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Depression [Time frame: Baseline, week 1, week 2, week 3, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in PROMIS Anxiety Score [Time frame: Baseline, week 1, week 2, week 3, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Acceptability of Intervention Measure [Time frame: week 4 (of intervention period)]
- Change in Growth Mindset Scale for Well-Being [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- HMP engagement measure [Time frame: Week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Cannabis Use Disorder Identification Test - Revised (CUDIT-R) [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Alcohol Use Disorders Identification Test (AUDIT) [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Healthy Minds Index (HMI) Score [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in PROMIS Global Health Score [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Ruminative Response Scale (RSS) Score [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Big Five Inventory-2 Extra Short Form (BFI-2-XS) [Time frame: Baseline, week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
- Change in Mindfulness Adherence Questionnaire (MAQ) [Time frame: Week 4 (of intervention period), and 3 month follow-up (up to 4 months on study)]
Eligibility criteria
Inclusion criteria
- Elevated symptoms of depression (PHQ-9 greater than or equal to 5)
- proficiency in English
- access to a smartphone and internet
- ability to receive text messages
Exclusion criteria
- Prior experience with meditation
- Prior use of the Healthy Minds Program app
- History of psychosis or mania
- Plans to travel in the next six weeks
- Suicidal ideation or thoughts of self-harm indicated by PHQ-9 item 9 and BDI item 9
- Failure to select the correct code word mentioned in the welcome video
- Not a US citizen
- Non-permanent resident
- Self-identification as artificial intelligence (AI)
- Has a hearing impairment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Factorial
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- Center for Healthy Minds — Madison
Identifiers
NCT: NCT07051330 · 2025-0660 · A171600