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Recruiting NCT07049224

The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals

No phase Interventional Muscle Protein Synthetic Response to Protein

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Meat diet, Plant diet.
Who it may be relevant to
Registry conditions: Muscle Protein Synthetic Response to Protein. Basic parameters: 65 years — 85 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Netherlands
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function. Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.

Interventions

  • Other Meat diet
    Participants will be subjected to a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise.
  • Other Plant diet
    Participants will be subjected to a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise.

Primary outcome measures

  • Integrated muscle protein synthesis rate in rested leg [Time frame: The 2 intervention periods over which FSR is determined will each last 10 days]
Secondary outcome measures (7)
  • Integrated muscle protein synthesis rate in exercised leg [Time frame: The 2 intervention periods over which FSR is determined will each last 10 days]
  • Blood glucose [Time frame: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood insulin [Time frame: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood lipid profile [Time frame: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood inflammatory markers [Time frame: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood amino acid profile [Time frame: The 2 intervention periods after which the outcomes are determined will each last 10 days]
  • Blood pressure [Time frame: The 2 intervention periods after which the blood pressure is determined will each last 10 days]

Eligibility criteria

Inclusion criteria

  • Male or female sex
  • Aged between 65 and 85 y inclusive
  • BMI between 18.5 and 30 kg/m2 inclusive

Exclusion criteria

  • Not willing to consume meat/animal-based products during the study period
  • Any food allergies (e.g. milk, gluten, etc.)
  • Participating currently or in the 3 months prior to the study in a structured progressive exercise program.
  • Smoking
  • History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the study team and responsible physician)
  • Diagnosed with phenylketonuria (PKU)
  • Donated full blood 3 months prior to test day
  • Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the study team and responsible medical doctor.
  • Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
  • Fasting blood glucose >7 mmol/L

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Single blind
Primary purpose
Basic science

Study locations

Netherlands · 1 center
  • Maastricht University Medical Centre+ — Maastricht

Identifiers

NCT: NCT07049224 · METC 24-025 · NL87069.068.24

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗