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Recruiting NCT07049003

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

Phase I Interventional Tremor Essential Tremor

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Deep Brain Stimulation.
Who it may be relevant to
Registry conditions: Tremor, Essential Tremor. Basic parameters: from 21 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.

Interventions

  • Device Deep Brain Stimulation
    Deep Brain Stimulation of the Deep Cerebellar Nuclei

Primary outcome measures

  • The incidence and nature of treatment-related adverse events [Time frame: From DBS Implant Surgery through study completion, an average of 17 months]
Secondary outcome measures (3)
  • Fahn Tolosa Marin Tremor Rating Scale [Time frame: From DBS Implant Surgery through study completion, an average of 17 months]
  • DBS-evoked potentials [Time frame: From DBS Implant Surgery through study completion, an average of 17 months]
  • 4-8 HZ (theta) tremor related oscillations [Time frame: From DBS Implant Surgery through study completion, an average of 17 months]

Eligibility criteria

Inclusion criteria

  • Age 21 years and older;
  • Ability to give informed consent;
  • Diagnosis of ET, cerebellar tremor, or MS-related tremor with a failed a prior intervention (VIM DBS or HIFU thalamotomy) or determined to not be suitable candidates for VIM DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor.
  • Tremor history of at least three years;
  • Tremor that is refractory to medical management;
  • A score of ≥24 on the Mini Mental State Examination;
  • Inability to successfully perform ADLs without assistance or has lost interest in social, professional, or personal activities due to tremor

Exclusion criteria

  • Any other neurological condition that could reduce the safety of study participation including central nervous system vasculitis and intracranial malignancy
  • A condition that, in the opinion of the clinical investigator, would significantly increase the risk or interfere with study compliance, safety, or outcome;
  • A diagnosis of dementia;
  • Tremors due to other neurological conditions such as Parkinson's disease, dystonia, or other conditions not consistent with ET, cerebellar outflow tremor, or MS-related tremor.
  • Diagnosis of epilepsy;
  • Major active and untreated psychiatric illness that may interfere with study, such as psychotic disorders or severe personality disorders;
  • Untreated or inadequately treated depression defined by a score of 20 or greater on the Beck Depression Inventory-II at the time of enrollment;
  • At risk for suicide defined by a score greater or equal to 3 on the Columbia Suicide Severity Rating Scale (C-SSRS);
  • Pregnancy;
  • Unable to communicate with investigators or staff;
  • Surgical contraindications to DN DBS;
  • Contraindication to magnetic resonance (MRI) imaging, e.g., weight incompatible with scanner, implanted metallic devices or electrical devices (pacemaker, defibrillator, spinal cord stimulator, prior DBS) or intolerance to MRI contrast agent;
  • Enrolled in another device, biologic or pharmaceutical study within 30 days of consent in the current study, (i.e., patient cannot be enrolled if participation in another study was not completed at least 30 days prior to consent.);
  • Evidence of behavior(s) consistent with alcohol or substance abuse/dependence as defined by the criteria outlined in the DSM-V within the preceding six months;
  • Injection of botulinum toxins into the arm, neck or face within six months prior to baseline;

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 1 center
  • Cleveland Clinic — Cleveland

Identifiers

NCT: NCT07049003 · 25-182

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗