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Not yet recruiting NCT07046221

Tislelizumab Combined With Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma Followed by CRT or Surgery

Phase II Interventional Esophagus Cancer

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Tislelizumab, Albumin-Bound Paclitaxel, cis-platinum, Surgery.
Who it may be relevant to
Registry conditions: Esophagus Cancer. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Tislelizumab Combined With Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma Followed by CRT or Surgery: A Prospective, Open-label, Multicenter Clinical Study

Overview

To explore the non-inferiority of the 2y-OS rate of tislelizumab combined with chemotherapy after sequential CRT in the treatment of resectable esophageal squamous cell carcinoma compared with the surgical group

Interventions

  • Drug Tislelizumab
    200mg，d1，q3w，1years
  • Drug Albumin-Bound Paclitaxel
    125mg/m2，d1，d8，q3w，2cycles
  • Drug cis-platinum
    75mg/m2，d1，q3w，2cycles
  • Procedure Surgery
    Radical resection of esophageal cancer
  • Radiation Radiation
    50.5Gy/28f
  • Drug Nedaplatin
    80-100mg/m2，d1，q3w，2cycles
  • Drug Carboplatin
    AUC=5，d1，q3w，2cycles

Primary outcome measures

  • Overall survival rate of 2 years [Time frame: 2 years]
Secondary outcome measures (1)
  • objective response rate [Time frame: every 2 weeks until 3 years]

Eligibility criteria

Inclusion criteria

  • The subjects were included in this study and signed the informed consent form.
  • Male or female patients aged between 18 and 75 years old;
  • Patients diagnosed with esophageal squamous cell carcinoma by histopathology;
  • According to the 8th edition of the AJCC Esophageal cancer TNM staging system, it is located in cT2N+ or cT3-4aNanyM0 (confirmed by enhanced CT/MRI of the chest and abdomen), and the lesion is located in the thoracic segment.
  • ECOG score: 0-1.
  • The main organs function normally, that is, they meet the following standards:
  • Blood routine (no blood transfusion was performed within 14 days before treatment, no granulocyte colony-stimulating factor \[G-CSF\] was used, and no other drugs were used for correction);

The absolute neutrophil count (ANC) was ≥1.5×109/L;

Hemoglobin (HB) ≥9.0 g/dL;

Platelet count (PLT) ≥100×109/L;

  • Blood biochemistry

Creatinine clearance rate ≥60 mL/min;

Total bilirubin (TBIL) ≤ 1.5×ULN;

Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level ≤2.5×ULN;

  • The expected survival period is ≥3 months;
  • Female subjects with reproductive capacity and male subjects whose partners are of childbearing age need to adopt a medically approved contraceptive measure during the study treatment period and for at least 3 months after the last treatment

Exclusion criteria

  • There are clinically uncontrolled pleural effusions, pericardial effusions or ascites that require repeated drainage or medical intervention (within 2 weeks before randomization);
  • It is known that there is intolerance or resistance to the chemotherapy specified in the trial protocol;
  • Have received any other ESCC anti-tumor treatments (e.g., targeted treatments for PD-1, PD-L1, PD-L2, or other tumor immunotherapy, radiotherapy, targeted therapy, ablation, or other systemic or local anti-tumor treatments);
  • Patients with active autoimmune diseases or a history of autoimmune diseases that may recur, or a known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;
  • Have a history of interstitial lung disease, non-infectious pneumonia or uncontrolled systemic diseases, including pulmonary fibrosis, acute lung diseases, etc.
  • Before enrollment, there was a severe chronic or active infection (including tuberculosis infection, etc.) that required systemic antibacterial, antifungal or antiviral treatment;
  • A known history of HIV infection;
  • Having suffered from other malignant tumors within the past five years (excluding cured basal cell carcinoma of the skin, carcinoma in situ of the breast and carcinoma in situ of the cervix);
  • Have received live vaccines within 28 days before enrollment;
  • Participated in other therapeutic clinical trials within 4 weeks;
  • Those that the researchers consider unsuitable for inclusion.
  • Distant metastasis exists (except for supraclavicular lymph nodes).

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07046221 · EC-01

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗