Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Enhanced Rehabilitation Program.
- Who it may be relevant to
- Registry conditions: Out of Hospital Cardiac Arrest, Inhospital Cardiac Arrest. Basic parameters: 18 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comprehensive Interpretation of the Importance of Skeletal Muscle Mass on Prognosis and Recovery in Cardiac Arrest Survivors: From Machine Learning to Clinical Trial
Overview
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.
Interventions
- Behavioral Enhanced Rehabilitation Program
Participants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients.
Primary outcome measures
- skeletal muscle mass [Time frame: 21 days]
Eligibility criteria
Inclusion criteria
- Non-traumatic adult patients who experienced sudden cardiac arrest
- Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation
- Admitted to the ICU
- Survived beyond 72 hours without successful weaning from mechanical ventilation
Exclusion criteria
- Age under 18 years
- Pregnancy
- Expected to be weaned from mechanical ventilation within 48 hours
- Terminal-stage cancer or unwillingness to receive aggressive treatment
- Unavailability of ICU care due to overcrowding in the emergency intensive care unit
- Refusal to participate in the study by the patient or family members
- Presence of an implanted pacemaker or defibrillator
- Open wounds, severe edema, or deep vein thrombosis in the lower limbs
- Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Supportive care
Study locations
Taiwan · 1 center
- Department of Emergency Medicine, National Taiwan University Hospital — Taipei
Identifiers
NCT: NCT07034170 · 202501085RIND