Serum miR-455-5p and Cardiac Structure and Function Parameters in Patients With Hypertensive Heart Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Hypertension, Heart Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Study on the Correlation Between Serum miR-455-5p Level and Cardiac Structure and Function Parameters in Patients With Hypertensive Heart Disease
Overview
Hypertensive heart disease (HHD) is the leading cause of mortality and morbidity worldwide. In 2017, the prevalence of HHD worldwide was 217.9 per 100,000 people, an increase of 7.4% over 1990, which has brought huge financial burden and social and economic losses to the world. Therefore, HHD is a major public health challenge worldwide. In our previous studies, we found that miR-455-5p, a microRNA, could functioned as an inducer to promote cardiac hypertrophy. Because cardiac hypertrophy was a common phenomenon in patients with HHD, so it is interesting to clarify whether miR-455-5p could be employed as a marker to indicate the function and/or structure of heart in the development of HHD. Thus, the purpose of this study was to collect blood samples of hypertensive patients, as well as analysis the correlation between serum miR-455-5p level and cardiac function. The research could help doctors better predict the course of hypertensive heart disease and provide more effective treatments for different patients.
Detailed description
The purpose of this study was to collect blood samples of hypertensive patients, in order to clarify the correlation between serum miR-455-5p level and cardiac function. Generally, by using q-PCR assay, miR-455-5p level of each participants will be collected. Besides, SBP, DBP, LVPWd, LVIDd, IVSTd was detected by echocardiography and EF, FS, LVMi, RWT level was further calculated by LVIDd, LVPWd and IVSTd. Finally, the correlation of miR-455-5p level of HHD patients and LVPWd, LVIDd, IVSTd, EF, FS, LVMi, RWT, SBP, DBP was analysed.
Primary outcome measures
- Measurement of serum miR-455-5p level [Time frame: the miR-455-5p level is collected at week 0, 6, 12 and 24.]
- Measurement of LVPWd and LVPWs [Time frame: the LVPWd and LVPWs are collected at week 0, 6, 12 and 24.]
- Measurement of LVIDd and LVIDs [Time frame: the LVIDd and LVIDs are collected at week 0, 6, 12 and 24.]
- Measurement of IVSTd and IVSTs [Time frame: the IVSTd and IVSTs are collected at week 0, 6, 12 and 24.]
- Calculation of LVMi [Time frame: the LVMi is calculated at week 0, 6, 12 and 24.]
- Measurement of LVEF [Time frame: the EF is calculated at week 0, 6, 12 and 24.]
- Measurement of FS [Time frame: the FS is calculated at week 0, 6, 12 and 24.]
- SBP [Time frame: the SBP is collected at week 0, 6, 12 and 24.]
- DBP [Time frame: the DBP is collected at week 0, 6, 12 and 24.]
Eligibility criteria
Inclusion criteria
- 1\. age ≥18 years; 2. male or female; 3. systolic blood pressure ≥140mmHg or (and) diastolic blood pressure > 90mmHg; 4. history of hypertension>1year, NYHA grade I-IV
Exclusion criteria
- hypertensive heart diseases patients with other metabolic diseases or congenital diseases were excluded from the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
China · 1 center
- the University of Hongkong-Shenzhen Hospital — Shenzhen
Identifiers
NCT: NCT07033676 · caisd@hku-szh.org · 82300446 · 2022A1515111093 · RCBS20231211090745071