A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No intervention measures were used..
- Who it may be relevant to
- Registry conditions: Kidney Injury, Acute. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients: Development, Validation, and the Incremental Value of Frailty Assessment
Overview
Primary objectives of this study is to develop and validate a predictive model for acute kidney injury after non-cardiac surgery based on machine learning. Secondary objectives of this study is to incorporate frailty assessment as a new predictor into the model and measure its incremental value was measured.
Detailed description
The data in this study are divided into two parts: retrospective and prospective. The retrospective data served as the development set, sourced from the electronic medical records of adult patients who underwent non-cardiac surgery during hospitalization between July 2015 and June 2025. The prospective data constituted an external (temporal) validation set, with data collection commencing in July 2025 and expected to conclude in February 2026.
Interventions
- Other No intervention measures were used.
The exposure factors were the perioperative related operations experienced by the patients and their individual conditions
Primary outcome measures
- Acute kidney injury [Time frame: Within 7 days after the operation]
Secondary outcome measures (4)
- Postoperative complications [Time frame: Perioperative period]
- Postoperative mortality [Time frame: Perioperative period]
- Hospitalization costs [Time frame: Perioperative period]
- Hospital stays [Time frame: Perioperative period]
Eligibility criteria
Inclusion criteria
- 18 years old or above
- Undergo non-cardiac surgery
Exclusion criteria
- At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
- End-stage renal disease (ESRD) that has received dialysis within the past year
- Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
- Acute kidney injury occurred within 7 days before the operation
- The surgical procedure is renal surgery
- The operation time is less than 2 hours
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Zhongda Hospital Southeast University — Nanjing
Identifiers
NCT: NCT07030166 · 2025ZDSYLL200-P01