Association of Genetic Variants With Myopia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Oral swab DNA analyzed for myopia-related gene variants.
- Who it may be relevant to
- Registry conditions: Myopia. Basic parameters: 6 years — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Genetic Variants and Their Association With Myopia Risk, Progression, and Optimal Interventions in Children
Overview
This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length). It will also examine how different treatments-such as low-dose atropine drops, orthokeratology lenses, specialized glasses, and increased outdoor time-interact with these genes. Finally, the research will develop a genetic risk score to help tailor personalized myopia prevention and treatment plans.
Interventions
- Genetic Oral swab DNA analyzed for myopia-related gene variants
Beyond detecting links between gene variants and myopia development, the testing analyzes how these variants influence treatment effectiveness. The aim is to enable early risk prediction and personalized treatment guidance for children through oral DNA testing.
Primary outcome measures
- Polygenic Risk Score (PRS) for Myopia Progression [Time frame: Every 6 months for 3 years]
Secondary outcome measures (1)
- Genotype-Guided Decision Tree for Myopia Control Interventions [Time frame: Every 6 months for 3 years]
Eligibility criteria
Inclusion criteria
- Age 6-18 years.
- Any Spherical equivalent refraction (SER)
- Parental consent for genetic testing.
Exclusion criteria
- Suspected genetic syndromes (e.g., Stickler, Marfan).
- Other eye diseases (e.g., glaucoma, cataracts, retinal abnormalities, strabismus).
- Prior refractive surgery
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 2 centers
- Beijing New Vision Eye Hospital — Beijing
- Beijing Visionly Plus Eye Hospital — Beijing
Identifiers
NCT: NCT07030153 · Precvision202501