Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Peripheral magnetic stimulation (90% of RMT + 1 Hz), Peripheral magnetic stimulation (90% of RMT + 10 Hz), Peripheral magnetic stimulation (90% of RMT + 25 Hz), Peripheral magnetic stimulation (100% of RMT + 1 Hz).
- Who it may be relevant to
- Registry conditions: Healthy Individuals. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.
Detailed description
This clinical trial is a crossover trial comparing 9 single-session rPMS protocols over the extensor carpi radialis muscle, testing three frequencies (1Hz, 10Hz, 25Hz), intensities (90%, 100%, 110% of resting motor threshold) across sequential phases.
Participants: Healthy adults (18-40 years) undergo pre-/post-intervention assessments: cortical (MEPs, ICI/ICF) excitability.
Design: Crossover, double-blind.
Analysis: ANOVA or Friedman tests (SPSS v20.0; α=0.05).
Significance: Clarifies parameter-specific neuromodulatory effects, guiding future rehabilitation protocols for neurological conditions.
Ethics: Approved by Federal University of Pernambuco's ethics committee (Resolution 466/12). Data stored securely for 5 years.
Interventions
- Device Peripheral magnetic stimulation (90% of RMT + 1 Hz)
Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses. - Device Peripheral magnetic stimulation (90% of RMT + 10 Hz)
High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses. - Device Peripheral magnetic stimulation (90% of RMT + 25 Hz)
High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses. - Device Peripheral magnetic stimulation (100% of RMT + 1 Hz)
Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses. - Device Peripheral magnetic stimulation (100% of RMT + 10 Hz)
High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses. - Device Peripheral magnetic stimulation (100% of RMT + 25 Hz)
High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses. - Device Peripheral magnetic stimulation (110% of RMT + 1Hz)
Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses. - Device Peripheral magnetic stimulation (110% of RMT + 10Hz)
High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses. - Device Peripheral magnetic stimulation (110% of RMT + 25Hz)
High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Primary outcome measures
- Cortical excitabilty [Time frame: Baseline (T0), immediately post-stimulation (T1), 15 minutes (T2), and 30 minutes (T3) post-stimulation.]
Eligibility criteria
Inclusion criteria: Healthy adults aged 18-40 years, both sexes, right-handed (confirmed via Edinburgh Handedness Inventory), and for females, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability.
Exclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Double blind
- Primary purpose
- Basic science
Study locations
Brazil · 1 center
- Universidade Federal de Pernambuco — Recife
Identifiers
NCT: NCT07025759 · Parameters_pMS