Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Socket preservation.
- Who it may be relevant to
- Registry conditions: Healing Wound. Basic parameters: 20 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study will examine whether using PRF and your age are going to affect the healing and regeneration benefits gained from PRF.
Detailed description
Platelet-rich fibrin (PRF) is commonly used to enhance gum tissue healing and reducing pain after tooth extraction and before placing a dental implant. 44 patients requiring a tooth extraction will be recruited and randomized to receive a collagen plug with or without platelet-rich fibrin.
Interventions
- Procedure Socket preservation
After tooth extraction, the extraction socket will be filled with a collagen plug in one group or a platelet-rich fibrin plug in the other.
Primary outcome measures
- Alveolar ridge dimension changes [Time frame: 4 months]
- Soft tissue dimension changes [Time frame: 4 months]
Secondary outcome measures (4)
- Histological bone density. [Time frame: 4 months]
- Presence of bone turnover proteins. [Time frame: 4 months]
- Amount of growth factors [Time frame: At baseline surgery]
- Wound healing index [Time frame: 1 week, 2 weeks, 4 weeks, and 8 weeks]
Eligibility criteria
Inclusion criteria
- Age range: 20 to 80 years.
- Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
- Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)
- Patients interested in implant placement following tooth extraction.
Exclusion criteria
- Allergies or hypersensitivities to study related medications.
- Hematologic disorders/blood dyscrasias.
- Active infectious diseases of any kind.
- Liver or kidney dysfunction/failure.
- Uncontrolled diabetes (HbA1c > 8).
- Active cancer treatment - such as active chemotherapy or radiation therapy.
- Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).
- Metabolic bone diseases that affect bone healing such as osteoporosis.
- Pregnant or lactating women (self-reported).
- Smoke 10 or more cigarettes per day (self-reported).
- Poor oral hygiene.
- Systemic diseases that compromise the immune system
- Anti-coagulant therapy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- University of Michigan School of Dentistry — Ann Arbor
Identifiers
NCT: NCT07023757 · HUM00264197