Assessment of Thyroid Dysfunction in Patients Undergoing Haemodialysis at Sohag University Hospital
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Thyroid profile.
- Who it may be relevant to
- Registry conditions: Dialysis; Complications. Basic parameters: 13 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Thyroid dysfunction is a prevalent endocrine disorder that significantly impacts the health of patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The prevalence of thyroid dysfunction in dialysis patients has been reported to range from 20% to 60%, highlighting the need for routine screening and management in this vulnerable group (Kuo et al., 2024). Thyroid hormones play a crucial role in regulating various physiological processes, and their dysregulation can lead to complications such as cardiovascular disease, anemia, and impaired quality of life, which are particularly concerning in the dialysis population (Smith et al., 2024). The relationship between CKD and thyroid dysfunction is complex and multifactorial. Uremic toxins can interfere with the hypothalamic-pituitary-thyroid axis, leading to alterations in thyroid hormone production and metabolism. Recent studies have shown that inflammation and oxidative stress associated with CKD can further exacerbate thyroid dysfunction (Johnson et al., 2024). Understanding these mechanisms is essential for developing effective management strategies for thyroid health in dialysis patients.
Interventions
- Diagnostic test Thyroid profile
Thyroid dysfunction in patients undergoing hemogdialysis in sohag university hospital
Primary outcome measures
- Number of Participants With Thyroid Dysfunction Diagnosed by Serum TSH, Free T3, and Free T4 Levels [Time frame: Up to 6 months from enrollment]
Secondary outcome measures (1)
- Number of Participants With Thyroid Dysfunction Stratified by Dialysis Duration and Ultrafiltration Rate [Time frame: Up to 6 months from enrollment]
Eligibility criteria
Inclusion criteria
- Adults aged 18 years and older.
- Patients diagnosed with end-stage renal disease (ESRD) on regular hemodialysis for at least 3 months.
Exclusion criteria
- Known Thyroid Disorders: Patients with a history of thyroid disease (e.g., hypothyroidism, hyperthyroidism) prior to starting dialysis.
- Recent Thyroid Treatment: Patients who have received treatment for thyroid dysfunction (e.g., thyroid hormone replacement, antithyroid medications) within the last six months.
- Patients with acute kidney injury (AKI) or those who are not on regular dialysis.
- Pregnant or lactating women.
- Patients with systemic illnesses or medications that could interfere with thyroid function tests (e.g., corticosteroids, lithium).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Egypt · 1 center
- Hospital — Sohag
Identifiers
NCT: NCT07022236 · Soh-Med--25-4-012MS