Sepsis and Hospital Mortality
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: conductivity and dieletric constant.
- Who it may be relevant to
- Registry conditions: Sepsis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Sepsis Mortality in Hospitals: a Quality Indicator in Acute Care Settings
Overview
Sepsis is one of the leading causes of hospital mortality, with a rate of approximately 20% (World Health Organization) among vulnerable patients admitted to high-intensity care units such as CCUs and inpatient wards. Currently, diagnostic criteria such as the Systemic Inflammatory Response Syndrome (SIRS) and the Sequential Organ Failure Assessment (SOFA) score, although widely used, lack sufficient specificity and accuracy. No established parameters are available for early and timely diagnosis. This study aims to address this gap by investigating the variability of blood plasma conductivity and dielectric constant using microwave probes previously validated for non-invasive glucose monitoring. The acquired data will be analyzed using the Anritsu VectorStar VNA to identify innovative and reliable parameters associated with the presence of severe infections.
Interventions
- Diagnostic test conductivity and dieletric constant
collecting blood samples and directly measuring plasma conductivity and dielectric constant using microwave probes already validated for non-invasive glucose monitoring.
Primary outcome measures
- Comparative Analysis of Plasma Bioelectrical Properties in Sepsis [Time frame: through study completion, an average of 10 days]
Secondary outcome measures (1)
- Correlation Between Biophysical Parameters and Conventional Infection and Inflammation Biomarkers [Time frame: through study completion, an average of 3 months]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years
- Cardiology patients without documented infection (Control Group)
- Patients with sepsis
- Patients with nosocomial infection
- Patients with myocarditis, endocarditis, or pericarditis
- Ability to provide written informed consent
Exclusion criteria
- Patients with severe or chronic medical conditions that may interfere with study results, such as autoimmune diseases, renal or hepatic failure
- Patients taking medications that could affect the measured biophysical parameters, such as corticosteroids or immunosuppressants
- Patients with cancer
- Patients with diseases involving the immune system (e.g., lymphomas, leukemias)
- Patients with congenital or acquired immunodeficiencies (e.g., HIV)
- Patients who are unable to read and sign the informed consent form
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Italy · 1 center
- ''Annunziata'' Hospital — Cosenza
Identifiers
NCT: NCT07022041 · 59/2025