The Effectiveness of Carbonate Apatite Bone Graft for Alveolar Ridge Preservation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Socket preservation.
- Who it may be relevant to
- Registry conditions: Healing Wound. Basic parameters: 20 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Effectiveness of Carbonate Apatite Bone Graft for Alveolar Ridge Preservation: A Clinical, Radiographic, and Histomorphometric Study
Overview
This study will examine whether the use of synthetic carbon apatite bone graft material will lead to more bone formation compared to human derived allograft and bovine derived xenograft material.
Detailed description
Bone grafts are commonly placed to increase the amount of bone right after tooth extraction and prepare the site for future dental implant placement.
45 patients requiring a tooth extraction will be recruited and randomized to receive either allograft, xenograft, or synthetic bone grafting.
Interventions
- Device Socket preservation
After tooth extraction, the socket will be filled with a collagen plug and bone graft.
Primary outcome measures
- Clinical alveolar ridge dimension changes [Time frame: 4 months]
Secondary outcome measures (3)
- Histological bone density [Time frame: 4 months]
- Presence of bone turnover proteins [Time frame: 4 months]
- Alveolar volumetric changes following tooth extraction [Time frame: 4 months]
Eligibility criteria
Inclusion criteria
- Age between 20 and 80 years old
- Patients requiring tooth extraction (incisors, canines, and premolars) due to caries, periodontal disease, tooth fracture, or unrestorable condition.
- Extraction sockets must be infection-free with dehiscence less than 5mm.
- Patients interested in implant placement after tooth extraction.
Exclusion criteria
- Known allergies or hypersensitivities to medications related to the study (e.g., chlorhexidine)
- Hematologic disorders or blood dyscrasias.
- Active infectious diseases.
- Liver or kidney dysfunction/failure.
- Uncontrolled diabetes (i.e., HbA1c > 8).
- Undergoing active cancer treatment, including chemotherapy or radiotherapy within the last 12 months from the procedure.
- Use of medications affecting bone healing (e.g., bisphosphonates, long-term anti-inflammatory medications).
- Metabolic bone diseases affecting bone healing, such as osteoporosis (self-reported).
- Pregnant or lactating women (self-reported).
- Current smokers of 10 or more cigarettes per day and former smokers who quit less than 10 years ago (self-reported).
- Poor oral hygiene.
- Presence of fenestration defects equal to or greater than 5mm.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- University of Michigan School of Dentistry — Ann Arbor
Identifiers
NCT: NCT07020650 · HUM00267966