Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ovarian Platelet-rich plasma (PRP) injections.
- Who it may be relevant to
- Registry conditions: Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization. Basic parameters: 18 years — 47 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Ovarian Platelet-Rich Plasma (oPRP) Injections Improvement In IVF Patients Based On Time-Lapse Incubator Culture for Automated Tracking and AI for Embryo Quality Assessment : A Non-Randomized Propsective Self-Controlled Interventional Study
Overview
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
Detailed description
. oPRP Treatment \& Second IVF Cycle (Study Cycle)
* Following the first IVF cycle, patients will undergo their first oPRP injection:
* Timing: 1-2 weeks after the onset of the next menstrual cycle. * Procedure: Under IV sedation, a patient's autologous PRP will be prepared and injected directly into both ovaries under transvaginal ultrasound guidance. * Second IVF Cycle (oPRP Study Cycle)
* The same ovarian stimulation protocol will be used for consistency. * A second oPRP injection will be performed on stimulation days 2-5 to enhance folliculogenesis. * Ovulation will be triggered at the same follicular size thresholds, and oocyte retrieval will follow identical protocols. * Fertilization methodology will be identical to the first cycle unless no fertilization is identified in the first cycle. * Embryo Development Analysis: Up to 15 embryos will be cultured in the AI incubator, where time-lapse imaging will track their morphokinetics, and AI-based analysis will assess embryo viability and implantation potential.
Interventions
- Procedure Ovarian Platelet-rich plasma (PRP) injections
This is a procedure that our patients receive at our clinic. We want to use the AI software to evaluate embryo development before and after treatment to see if there is a difference in embryo quality after PRP treatment within the same patient.
Primary outcome measures
- Blastocyst formation and embryo quality [Time frame: 1 year]
Secondary outcome measures (1)
- Live birth rate per transfer [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- No none contraindications to IVF or PRP treatment
- Adequate ovarian reserves and AMH level
- Willingness to undergo two IVF cycles and oPRP treatment
Exclusion criteria
- Anovulation due to menopause or perimenopause
- Any health conditions that are contraindicated for IVF or oPRP treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Generation Next Fertility — New York
Identifiers
NCT: NCT07020546 · IORG0010499-012025