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Not yet recruiting NCT07018778

CMR-derived Quantitative Perfusion for Prediction of FFR

— Observational Chronic Coronary Syndrome

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Chronic Coronary Syndrome. Basic parameters: 18 years — 99 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Germany
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Quantification of Myocardial Blood Flow in Cardiovascular Magnetic Resonance for Prediction of Fractional Flow Reserve in Coronary Catheterisation

Overview

Patients will undergo quantitative perfusion assessment in cardiovascular magnetic resonance imaging (dual bolus or dual sequence approach) as well as invasive coronary angiography for assessment of fractional flow reserve (FFR) including assessment of coronary flow reserve (CFR) and microcirculatory resistance (IMR).

Primary outcome measures

  • Quantitative Perfusion [Time frame: assessment of CMR and invasive data within 24hours]
  • Dual bolus vs dual sequence [Time frame: assessment of CMR and invasive data within 24hours]
Secondary outcome measures (3)
  • Strain [Time frame: baseline CMR data]
  • Tissue characterisation [Time frame: baseline CMR data]
  • Cardiovascular Hospitalisation (CVH) [Time frame: 12 months]

Eligibility criteria

Inclusion criteria

  • clinical indication for vasodilatator CMR or invasive coronar angiography
  • capability to give informed consent

Exclusion criteria

  • general: non-compliance, <18 years of age, pregnancy
  • contraindications for CMR (non-CMR compatible device, chronic kidney disease (eGFR <30ml/min), allergies (medications)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Germany · 1 center
  • Kerckhoff Klinik — Bad Nauheim

Identifiers

NCT: NCT07018778 · AZ 107/24

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗