Micro Assays for HemATology Malignancies Antibody Treatment
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: blood sampling.
- Who it may be relevant to
- Registry conditions: Hematological Malignancy. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Hematological malignancy is a disease of the blood. In some cases, this pathology requires therapeutic management, which is not necessarily the case for you. Nevertheless, to improve the management of patients who need it, we are conducting research to assess the state of your immune system. Indeed, the role of the immune system is not limited to controlling infections, but is also important in controlling the proliferation of cancer cells, in hematology as in other types of cancer. Your immune system can play a spontaneous anti-tumor control role, but some so-called "immunotherapy" treatments aim to destroy cancer cells by stimulating the immune system, restoring its capabilities, and directing the immune response against tumor cells. For this immunotherapy treatment to be effective, since it uses your own immune cells (in most cases), these cells must be in a state to respond and be able to destroy the tumor. It is this ability to activate immune cells that is tested in this research protocol, using a simple test that could in future be used in routine clinical practice. But to understand why these immune cells don't work, we will also have to carry out genetic tests to analyze the various molecules that could interfere with the immune response, and try to inhibit the molecules that prevent the immune response.
Interventions
- Other blood sampling
Additional blood sampling as part of routine care
Primary outcome measures
- Percentages of immune effectors [Time frame: At the enrollement in the study]
Secondary outcome measures (1)
- Activation percentages (cytometry) vs. polymorphism expression percentage (molecular biology) [Time frame: At the enrollement]
Eligibility criteria
Inclusion criteria
- Male or Female over 18 years of age
- Patient with a hematological malignancy likely to benefit from immunotherapy (in any form; at the discretion of the referring physician)
- Before the start of 1st-line treatment, successive lines or before autograft (chemotherapy-free for at least 4 weeks in these cases).
- Patient has received information about the study and has not expressed opposition.
- Patient who is a beneficiary or entitled beneficiary of a social security scheme
Exclusion criteria
- Person in a period of exclusion from another research protocol at the time the non-opposition is signed.
- Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code, i.e. :
- Persons deprived of their liberty by judicial or administrative decision
- Persons subject to psychiatric monitoring under articles L3112-1 and L3113-1 who are not covered by the provisions of article L1121-8
- Minors
- Adults under legal protection or unable to express their consent.
- A person who cannot read and understand the French language well enough to be able to consent to take part in research.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 1 center
- Assisitance Publique Hôpitaux de Marseille — Marseille
Identifiers
NCT: NCT07018310 · RCAPHM25_0145 · 2025-A01044-45