Precision Analytic Research Methods in OCD
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exposure and Response Prevention.
- Who it may be relevant to
- Registry conditions: Obsessive Compulsive Disorder. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Dissecting Neurocognitive Components of Compulsivity Using Computational Modeling and EEG
Overview
Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.
Interventions
- Behavioral Exposure and Response Prevention
Exposure and response prevention (EX/RP) is the gold-standard behavioral treatment for OCD. It involves confronting the content of obsessions (distressing thoughts, images, or impulses) and resisting the urge to engage in compulsions (observable behaviors or mental acts that are repeated to reduce the anxiety/distress associated with compulsions).
Primary outcome measures
- Yale Brown Obsessive Compulsive Scale [Time frame: Week 1, Week 5, Week 10]
Secondary outcome measures (4)
- Obsessive Compulsive Inventory- Revised [Time frame: Week 1, Week 5, Week 10]
- Cambridge-Chicago Compulsivity Trait Scale [Time frame: Week 1, Week 5, Week 10]
- Self-Report Habit Index [Time frame: Week 1, Week 5, Week 10]
- Dimensional Obsessive- Compulsive Scale [Time frame: Week 1, Week 5, Week 10]
Eligibility criteria
Inclusion criteria
Participants must be:
- between the ages 18-55 years old
- English-speaking
- right-handed
- able to provide consent
Exclusion criteria
Individuals diagnosed with OCD will be excluded if:
- they meet diagnostic criteria for certain other psychiatric disorders
- are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
- if it is unsafe for them to participate in research
Healthy control participants will be excluded if:
- they have a current psychiatric disorder
- a lifetime history of certain psychiatric disorders
- are taking psychiatric medication or have in the past
- have a parent or sibling who has been diagnosed with OCD
- if it is unsafe for them to participate in research
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Icahn School of Medicine at Mount Sinai — New York
Identifiers
NCT: NCT07011901 · STUDY-24-01125 · K23MH133997