Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: varicocelectomy.
- Who it may be relevant to
- Registry conditions: Non-obstructive Azoospermia. Basic parameters: 20 years — 60 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia.
Overview
A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the most common correctable cause of male factor infertility. Male factor infertility affects up to half of all couples struggling to conceive, and 10-20% of men evaluated for infertility are found to be azoospermic.
Detailed description
Generally, azoospermia is classified as obstructive azoospermia (OA) or non-obstructive azoospermia (NOA). While OA is obviously caused by obstruction, NOA has many possible causes and is more difficult to manage.
Non-obstructive azoospermia (NOA) is most often a result of primary testicular dysfunction, Varicoceles are found in 20% of the general male population, in up to 40% of men with infertility, and specifically 4.3-13.3% of men with NOA.
The role of varicoceles in NOA has not been fully elucidated. The current best practice statement on the evaluation of azoospermic males from the AUA acknowledges that impaired spermatogenesis associated with varicoceles may be reversible but does not give a clear recommendation for management.
The primary advantage of varicocelectomy in cases of NOA is the possibility of getting motile sperms in the ejaculate. Other benefit of varicocele repairs in azoospermic men is that there are increased success rates of assisted reproductive techniques (ART) such as intracytoplasmic sperm injection (ICSI) or testicular sperm extraction (TESE).
Interventions
- Procedure varicocelectomy
to detect testicular sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia.
Primary outcome measures
- Sperm retrieval rate [Time frame: Two Weeks]
Secondary outcome measures (1)
- fertility rate [Time frame: 3 months from the operation]
Eligibility criteria
Inclusion criteria
- Men with non obstructive azoospermia.
- Clinically palpable varicocele ( unilateral or bilateral ).
Exclusion criteria
- Known cases of obstructive azoospermia.
- Non palpable varicocele.
- Uncorrectable female causes of infertility.
- genetic abnormalities like klinefelter syndrome.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Egypt · 1 center
- South Valley University Hospital — Qina
Identifiers
NCT: NCT07008495 · Non-Obstructive Azoospermia