A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Osteoarthritis. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.
Detailed description
1. To investigate the natural history of osteoarthritis (OA) in a large-sample cohort. 2. To identify OA phenotypes and their relationship with clinical symptoms and functional impairment. 3. To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression. 4. To evaluate the association between radiographic changes and OA symptoms. 5. To develop predictive models for OA progression and identify high-risk individuals for early intervention.
Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.
Primary outcome measures
- Incidence of Osteoarthritis [Time frame: Annually for 10 years]
Secondary outcome measures (12)
- Change in Joint Pain Severity (WOMAC Pain Subscale) [Time frame: Annually for 10 years]
- Change in Physical Function (WOMAC Subscale) [Time frame: Annually for 10 years]
- Change in Physical Function (SF-36 Physical Function Domain) [Time frame: Annually for 10 years]
- Timed Up and Go Test (TUGT) [Time frame: Annually for 10 years]
- Five Times Sit-to-Stand Test (5TSTS) [Time frame: Annually for 10 years]
- Radiographic Progression of Osteoarthritis [Time frame: Annually for 10 years]
- Changes in Body Mass Index (BMI) [Time frame: Annually for 10 years]
- Changes in Blood Pressure [Time frame: Annually for 10 years]
- Changes in Fasting Glucose [Time frame: Annually for 10 years]
- Changes in Total Cholesterol (TC) [Time frame: Annually for 10 years]
- Changes in Low-Density Lipoprotein Cholesterol (LDL-C) [Time frame: Annually for 10 years]
- Changes in High-Density Lipoprotein Cholesterol (HDL-C) [Time frame: Annually for 10 years]
Eligibility criteria
Inclusion criteria
- Aged 50 years and above
- Long-term resident of the study area
- Willing to participate and provide informed consent
Exclusion criteria
- Hearing, speech, or mental impairments preventing effective communication
- Unable to complete scheduled follow-up visits
- Pregnant or planning pregnancy during the study period
- Any other condition deemed unsuitable for participation by the researchers
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Beijing Tsinghua Chang Gung Hospital — Beijing
Identifiers
NCT: NCT07006701 · 25025-4-01