Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Modified Fasting Guidelines.
- Who it may be relevant to
- Registry conditions: Upper Endoscopy, GLP1-R-related Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The aim of this study is to determine whether a modified fasting protocol can reduce the potential risk of aspiration for patients currently prescribed GLP1-RAs.
Detailed description
The overall objective of this project is to identify a reasonable means by which patients on GLP1-RAs can be safely cared for in the perioperative period that can be agreed upon by all groups involved in perioperative patient care. This will be assessed in patients undergoing upper endoscopy specifically since assessment of gastric contents would be minimally invasive for this patient population receiving anesthetic care.
Interventions
- Other Modified Fasting Guidelines
Patients will follow a full-liquid diet 48 hours prior to their procedure, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure
Primary outcome measures
- Gastric contents [Time frame: Baseline]
Secondary outcome measures (3)
- Diagnosis of aspiration within 72 hours of procedure [Time frame: From the time of upper endoscopy until 72 hours post-procedure.]
- Aspiration pneumonitis diagnosis postoperatively [Time frame: 72 hours after completion of upper endoscopy]
- Postprocedural ICU admission [Time frame: Immediately after upper endoscopy]
Eligibility criteria
Inclusion criteria
- Patients undergoing elective upper endoscopy with gastroenterology team
Exclusion criteria
- Urgent or emergent procedure
- Inclusion of colonoscopy or antegrade small bowel enteroscopy in planned procedure
- Upper GI barium study performed in past 24 hours.
- Gastroparesis
- Achalasia
- Pancreatitis
- Use of outpatient pro-motility medications
- Patient refusal
- Inability for patient to provide own consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Mayo Clinic in Rochester — Rochester
Identifiers
NCT: NCT07006142 · 23-013192