The Role of hCG in Thawed Embryo Transfer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: HCG injection, No intervention.
- Who it may be relevant to
- Registry conditions: Infertility (IVF Patients). Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This prospective randomized trial will assess the relevance, if any, of a corpus luteum induced by hCG in transfers of thawed embryos.
Detailed description
The current study is designed to carefully isolate the effect of a corpus luteum by ensuring that the presence or absence of a corpus luteum is the only difference between two study arms. This should be reliably achieved by administering an injection of hCG in one study arm, while the other study arm has identical treatment except for omitting the hCG.
Interventions
- Drug HCG injection
5000 IU hCG injection - Other No intervention
No hCG administered in this group.
Primary outcome measures
- Blood pressure [Time frame: Third trimester of pregnancy]
Eligibility criteria
Inclusion criteria
- Female adult expecting to receive transfer of a thawed embryo.
- At least one available frozen blastocyst of transferrable quality.
- Non-menopausal female with at least one antral follicle.
- Use of pre-implantation genetic testing (PGT), embryos derived from donor oocytes and/or donor sperm, a gestational carrier, and history of prior transfer(s) regardless of outcome are allowed.
- Subsequent embryo transfers after failed transfers under this study are allowed, but not after a transfer that has resulted in ongoing pregnancy at ten weeks gestation under this study.
Exclusion criteria
- Minors (age<18 years).
- Use of embryo(s) frozen at another center.
- Patient insistent on transfer of two embryos.
- Patient or partner unable to provide informed consent in English.
- Patient already enrolled in any other research study for her embryo transfer.
- History of anti-phospholipid syndrome or any other indication for use of Lovenox in pregnancy.
- Patient for whom the physician assesses this protocol is inappropriate or unsafe.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Fertility Center of Las Vegas — Las Vegas
Identifiers
NCT: NCT07004192 · FCLV 2025-1