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Recruiting NCT07001943

Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

— Observational Intestinal Ischemia Critical Illness Enteral Nutrition Feeding Hemodynamics

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: enteral nutrition.
Who it may be relevant to
Registry conditions: Intestinal Ischemia, Critical Illness, Enteral Nutrition Feeding, Hemodynamics. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Functional Injury in Critically Ill Patients

Overview

This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.

Interventions

  • Other enteral nutrition
    We'll use an enteral nutrition intervention with intact protein formulations. Initiate nasogastric tube feeding at 20ml/h and continue for 24 hours. Adjust feeding strategies based on patients' SMA blood flow reactivity.

Primary outcome measures

  • feeding intolerance [Time frame: From enrollment to the end of treatment at 3 days]

Eligibility criteria

Inclusion criteria

  • Adults aged ≥18 years and ≤80 years.
  • Admitted to the study with a expected stay of more than 72 hours.
  • Require initiation of enteral nutrition support.

Exclusion criteria

  • Pre-existing severe gastrointestinal diseases.
  • Patients with gastrointestinal bleeding.
  • Patients with bowel obstruction.
  • Pregnant or lactating women.
  • Patients with contraindications to bedside Doppler ultrasound.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

China · 1 center
  • Peking union medical college hospital — Beijing

Identifiers

NCT: NCT07001943 · SMART(SMA Reactivity Trial)

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗