Metabolically Healthy Obesity Increases the Risks of MASLD and Hyperuricemia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolically Healthy Obesity, Hyperuricemia. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Metabolically Healthy Obesity Increases the Risks of MASLD and Hyperuricemia: A Cohort Study With Mediation Analysis
Overview
Although metabolically healthy obesity (MHO) is often considered a relatively benign obesity, its association with the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) and hyperuricemia remains unclear. This study examined the associations between MHO and other metabolic-obesity phenotypes with MASLD and hyperuricemia, and explored the mediating roles of metabolic indicators.This study included 11,712 and 13,846 participants from a health examination cohort at the First Affiliated Hospital of Ningbo University for MASLD and hyperuricemia analyses, respectively. Participants were classified into four metabolic-obesity phenotypes, with MHO defined as obesity without metabolic syndrome components. The outcomes were MASLD and hyperuricemia. Cox regression and mediation analyses were conducted to assess associations and mediating effects.
Primary outcome measures
- Incidence of MASLD and Hyperuricemia [Time frame: 7 years]
Eligibility criteria
Inclusion criteria
- Underwent comprehensive health examinations at the Physical Examination Center of the First Affiliated Hospital of Ningbo University between 2017 and 2024;
- Aged 18 years or older at baseline;
- Completed an abdominal ultrasound examination during the health check-up.
Exclusion criteria
- Underweight status at baseline, defined as BMI < 18.5 kg/m² ；
- Missing data on height, weight, or components of the metabolic syndrome ;
- Baseline diagnosis of MASLD or any other liver diseases
- Baseline diagnosis of hyperuricemia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000, Ningbo — Ningbo
Publications
- Liu Y, Qian T, Zheng Y, Liu A, Xu L, Ye G, Xie J. Metabolically healthy obesity increases the risks of MASLD and hyperuricemia: a cohort study with mediation analysis. BMC Endocr Disord. 2025 Nov 27;26(1):3. doi: 10.1186/s12902-025-02106-9. PMID 41310554
Identifiers
NCT: NCT07001865 · 2025-073RS-01 · MR-33-25-026108