Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Enhanced Mentor Mother Strategy.
- Who it may be relevant to
- Registry conditions: Hiv, Transmission Vertical, Viremia, Adherence, Treatment. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Kenya
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Pilot Implementation-Effectiveness Study of an Enhanced Mentor Mother Strategy
Overview
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya. Differentiated service delivery (DSD) is a care model that tailors services based on clients' needs, helping to improve both the quality and efficiency of care. This hybrid implementation-effectiveness study will test whether an enhanced MM strategy that uses DSD can be successfully carried out and improve health outcomes for mothers and infants. The study will take place at Burnt Forest Sub-District Hospital (BFSDH) in Kenya. Researchers will ask: * Can the enhanced MM strategy be delivered as planned and accepted by patients and staff? * Does the strategy improve clinical outcomes like keeping mothers in PMTCT care, achieving HIV viral suppression, completing infant HIV testing, and preventing HIV transmission to infants? Researchers will compare health outcomes before and after the strategy is introduced at BFSDH, and also compare outcomes at other similar clinics that continue with standard MM services. Women who choose to participate will meet with a MM during their routine antenatal and postnatal clinic visits. They will be offered the enhanced MM support, but can choose to receive standard care if they prefer.
Detailed description
This is a hybrid implementation-effectiveness study of an enhanced Mentor Mother (MM) strategy for delivering risk-based, differentiated prevention of mother-to-child transmission of HIV (PMTCT) services to pregnant and postpartum women living with HIV (WLHIV) and their infants. The study will be conducted at Burnt Forest Sub-District Hospital (BFSDH), an Academic Model Providing Access to Healthcare (AMPATH)-supported public health facility in Uasin Gishu County, Kenya.
Mentor Mothers (MMs) are peer advocates who support WLHIV in PMTCT programs, providing adherence counseling, psychosocial support, and retention assistance. Although MMs are a widely implemented, evidence-based intervention, current models generally do not differentiate services based on clients' individual risk profiles. The enhanced MM strategy evaluated in this study builds on the World Health Organization and Kenya Ministry of Health's recommendation for differentiated service delivery (DSD)-a patient-centered model that tailors services to individual needs.
This study will evaluate implementation outcomes (feasibility, acceptability, fidelity) while also gathering preliminary clinical effectiveness data of the enhanced MM strategy. The strategy includes structured, iterative risk stratification by MMs and PMTCT clinicians at each clinical encounter to identify clients at higher risk for poor PMTCT outcomes. Identified risk factors include HIV viremia, stigma and non-disclosure, and socioeconomic barriers. Based on the identified risk(s), MMs will deliver individualized, problem-focused support. WLHIV with no identifiable risk factors will receive a less-intensive service schedule aligned with national differentiated care guidelines.
Specific Aims:
* Aim 1: Use a mixed-methods approach to evaluate fidelity, feasibility, and acceptability of the enhanced MM strategy over a 15-month period. Data will include quantitative fidelity checklists, MM activity logs, chart audits, observation logs, and stakeholder focus group discussions. * Aim 2: Assess preliminary effectiveness of the enhanced MM strategy on key maternal and infant outcomes using aggregate, routinely collected clinical data from AMPATH's medical record system. Outcomes include maternal retention in care, maternal HIV viral suppression, infant uptake of HIV diagnostic testing, and HIV vertical transmission. A within-site pre-post analysis will compare outcomes at BFSDH during the 12 months before and after implementation (excluding the first 3 months of roll out). A contemporaneous across-site analysis will compare outcomes at BFSDH (enhanced MM strategy) and three comparable clinics providing standard MM services during the same 12-month period.
The study is supported by the NIH through a K23 award (K23HD109056), and builds on extensive formative research, including qualitative interviews and human-centered design workshops with WLHIV, MMs, PMTCT clinicians, and policymakers. Pilot implementation is being guided by local stakeholders and is expected to inform the design of a future pragmatic trial. The enhanced MM strategy, if successful, may provide a scalable model for improving PMTCT outcomes in resource-constrained settings.
Interventions
- Behavioral Enhanced Mentor Mother Strategy
The enhanced Mentor Mother strategy introduces a structured approach to differentiated PMTCT support, led by trained peer counselors/Mentor Mothers (MM). Mentor Mothers will be trained on how to perform risk stratification, and they will use a standardized form to identify and document psychosocial and clinical risk factors. Based on these, MMs then deliver tailored interventions, including additional counseling, community outreach, and referrals. Fidelity assessments and a process of audit and
Primary outcome measures
- Fidelity: Proportion of enhanced Mentor Mother strategy tasks completed and services correctly assigned/delivered, as assessed by checklists, audits, and observations. [Time frame: Fidelity to the enhanced MM strategy will be assessed throughout the 15-month implementation period, and a process of audit and feedback will be used to enhance fidelity and further refine the strategy.]
- Acceptability: Participant ratings of acceptability of the enhanced Mentor Mother strategy, assessed by AIM scores, satisfaction surveys, and focus group discussions. [Time frame: Acceptability of the enhanced MM strategy will be assessed at the end of the 15-month implementation period.]
- Feasibility: Participant ratings of feasibility of the enhanced Mentor Mother strategy, assessed by FIM scores and focus group discussions. [Time frame: Feasibility of the enhanced MM strategy will be assessed at the end of the 15-month implementation period.]
Secondary outcome measures (7)
- Proportion of mothers retained in care [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of mothers with HIV viral suppression [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of mothers who died [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of mothers who transferred out [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of infants receiving HIV diagnostic testing [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of infants infected with HIV (vertical transmission) [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
- Proportion of infants who died [Time frame: Assessed at baseline (pre-implementation), 6-months (interim analysis), and at the end of the 15-month implementation period.]
Eligibility criteria
Inclusion criteria
- Pregnant and postpartum women living with HIV (and their infants born during the study)
- ≥18 years of age
- Enrolled in PMTCT services at BFSDH
- Able to understand and provide informed consent in English or Kiswahili
Exclusion criteria
- Women who are not pregnant or postpartum
- <18 years of age
- Not enrolled in PMTCT services at BFSDH
- Unable to understand and provide informed consent in English or Kiswahili
- Cognitive impairment that would interfere with ability to participate in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Health services research
Study locations
Kenya · 1 center
- Burnt Forest Sub-District Hospital — Burnt Forest
Identifiers
NCT: NCT06999928 · 24102 · K23HD109056