JSKN003 Combined Treatment of HER2-positive Gastric Cancer

Official title

A Phase II Trial to Evaluate the Safety and Efficacy of JSKN003 Combination Therapy as First-line Treatment in HER2-positive Unresectable Locally Advanced or Metastatic Gastric Cancer or Resectable Gastric Cancer

Overview

This study is designed to evaluate the safety and efficacy of JSKN003 combination therapy as first-line treatment in HER2-positive unresectable locally advanced or metastatic gastric cancer or resectable gastric cancer.

Interventions

• Drug JSKN003
  JSKN003 is administered by intravenous infusion.
• Drug KN026
  KN026 is administered by intravenous infusion.
• Drug Capecitabine
  Capecitabine is for oral administration.
• Drug Enlonstobart
  Enlonstobart is administered by intravenous infusion.
• Drug Oxaliplatin
  Oxaliplatin is administered by intravenous infusion.
• Drug Trastuzumab
  Trastuzumab is administered by intravenous infusion.
• Drug Pembolizumab
  Pembolizumab is administered by intravenous infusion.

Primary outcome measures

• Objective Response Rate (ORR) of the first-line population [Time frame: Frame: Up to approximately 5 years]
• Incidence and severity of TEAE and SAE of the first-line population [Time frame: Up to approximately 5 years]
• pCR rate after neoadjuvant therapy of perioperative population [Time frame: Up to approximately 5 years]

Secondary outcome measures (12)

• Disease Control Rate (DCR) of the first-line population [Time frame: Up to approximately 5 years]
• Duration of Response (DoR) of the first-line population [Time frame: Up to approximately 5 years]
• Progression-free survival (PFS) of the first-line populations [Time frame: Up to approximately 5 years]
• Major pathological response (MPR) rate of perioperative population [Time frame: Up to approximately 5 years]
• R0 rate of perioperative population [Time frame: Up to approximately 5 years]
• Event-free survival (EFS) of perioperative population [Time frame: Up to approximately 5 years]
• Overall Survival (OS) [Time frame: Up to approximately 5 years]
• Incidence and severity of AE [Time frame: Up to approximately 5 years]
• Blood concentration of JSKN003 [Time frame: Up to approximately 2 years]
• Blood concentration of total antibodies for JSKN003 [Time frame: Up to approximately 2 years]
• Blood concentration of free toxins for JSKN003 [Time frame: Up to approximately 2 years]
• Serum concentration of KN026 [Time frame: Up to approximately 2 years]

Eligibility criteria

Inclusion criteria

• Age≥18 years old.
• Histologically or cytologically confirmed diagnosis of gastric cancer.
• The first-line population enrolls participants with HER2-positive unresectable locally advanced or metastatic gastric cancer who had not received systemic treatment, and Perioperative population enrolls participants with HER2-positive resectable gastric cancer who had not received treatment.
• HER2-positive (defined as IHC3+ or IHC 2+/FISH +).
• The first-line population: presence of at least 1 measurable lesion per RECIST 1.1. Tumor lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.
• ECOG PS of 0 - 1.
• Expected survival ≥ 3 months.
• Participants with adequate organ functions.
• Female and male patients of childbearing age agree to take adequate contraceptive measures during and upon completion of the study for 7 months after the last dose. Female participants of childbearing age must have a negative blood pregnancy test within 7 days before the first dose or randomization.
• Voluntarily agree to participate in the study and sign the informed consent.

Exclusion criteria

• Has received anti-tumor treatment such as systemic chemotherapy or other trial interventions within 28 days, or immunotherapy (e.g. interleukin, interferon, thymospipeptide, etc.), hormone therapy or targeted therapy within 14 days or 5 half-life (whichever is shorter) before the first dose or randomization.
• Has previously been treated with an anti-HER2 ADC loaded with topoisomerase I inhibitors.
• Participants with brain metastasis or spinal cord compression at screening (except for completed local treatment and discontinued glucocorticoids for at least 4 weeks before the first dose or randomization , and stable central nervous system imaging and brain metastasis symptoms for at least 4 weeks).
• Participants with PD-L1 CPS ≥1, who are receiving long-term immunotherapy (e.g., cyclosporine) or require daily systemic steroid therapy (e.g., >20 mg prednisone or equivalent), except those who treated with local glucocorticoids using nasal spray, inhalation, or other pathways.
• Participants with PD-L1CPS ≥1, who have an active autoimmune disease or have a history of autoimmune disease 2 years before the first dose or randomization and still require systemic treatment. However, participant with the following diseases is allowed to enroll: well-controlled type I diabetes, well-controlled hypothyroidism that requires hormone replacement therapy, skin diseases that do not require systemic treatment (such as vitiligo, psoriasis, or hair loss), or participant who is expected to not recur without external triggers.
• Participate in another clinical trial, unless it is an observational (non-intervention) clinical trial or is in the follow-up period of an intervention trial.
• Participants who have undergone major surgery or had invasive intervention within 28 days before the first dose or randomization. Or those who plan to undergo systematic or local tumor resection during the trial (Perioperative cohort does not apply).
• Any Chinese patent medicine with anti-cancer activity approved by the National Drug Administration (regardless of cancer type) has been used within 14 days before the first dose or randomization.
• Has a history of severe hypersensitivity reactions to either the drug substances or inactive ingredients in the drug product.
• Active bacterial, fungal or viral infection before the first dose or randomization. Participant who has recieved preventive infection treatment but has no clinical manifestations before the first dose or randomization could be considered to enroll.
• Has a history of immunodeficiency, including HIV-positive.
• Active hepatitis B or C infection. Participant with positive hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) need to test Hepatitis B virus DeoxyriboNucleic Acid (HBV-DNA), and HBV-DNA is higher than 500 IU/mL (or 2500 copies/ml) or upper limit of normal (UNL) (whichever is lower) ; Participants with positive for hepatitis C (HCV) antibody and whose Hepatitis C virus Ribonucleic Acid (HCV-RNA) is higher than 1000 copies/ml or UNL (whichever is lower).
• Has a history of tuberculosis treatment within 2 years before the first dose or randomization.
• Has activity or a history of interstitial lung disease at any stage and/or pulmonary function injury, a history of interstitial pneumonia requiring hormone therapy, or the imaging cannot rule out suspected interstitial lung disease/pneumonia at screening.
• Known to have low activity or lack of dihydropyrimidine dehydrogenase (DPD).
• Participants with peripheral neuropathy of grade > 1.
• Participants with clinically significant gastrointestinal diseases including but not limited to severe liver diseases, ulcerative colitis, inflammatory bowel disease and other gastrointestinal diseases 28 days before the first dose or randomization.
• Has a history of severe cardiovascular disease.
• History of any other malignant tumors within 5 years before the first dose or randomization.
• Live vaccination within 28 days before the first dose or randomization. Note: Seasonal influenza vaccine is a broadly inactivated vaccine and is allowed to be used;
• Unable to swallow orally, or there are conditions that have been judged by researchers to seriously affect gastrointestinal absorption (such as severe Crohn's disease, malabsorption syndrome, etc.).
• Pregnant or breastfeeding women.
• Otherwise considered inappropriate for the study by the investigator.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Open label

Primary purpose

Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT06998771 · JSKN003-003

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗