Not yet recruiting NCT06996106

Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

No phase Interventional Nasal Septum; Deviation Nasal Septal Srur

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: The protocol lists: Effect of Platelet Rich Fibrin on Septoplasty.
Who it may be relevant to: Registry conditions: Nasal Septum; Deviation, Nasal Septal Srur. Basic parameters: up to 65 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: Center list to be confirmed — check the primary protocol.
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Effect of Platelet Rich Fibrin on Septoplasty :A Comparative Study

Overview

The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Detailed description

Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.

Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.

Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Interventions

Other Effect of Platelet Rich Fibrin on Septoplasty
it is a randomized trial of usage of platelet rich fibrin in septoplasty

Primary outcome measures

Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty [Time frame: postoperative at 1st week , 1st month , 3rd month]

Eligibility criteria

Inclusion criteria

Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.

Exclusion criteria

History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation: N/A
Model: Parallel assignment
Masking: Single blind
Primary purpose: Other

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT06996106 · PRF in septoplasty

Primary sources (government registries)

ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗