Medical Marijuana and Open Road Driving Task
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Medical Cannabis. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
An Open Road Driving Performance Task to Examine Long-term Medical Marijuana Use and Prescription Opioid Positivity in Adults 50 and Older
Overview
Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain management in this population. To date, no studies systematically assess driving performance in a rigorous and ecologically valid manner accounting for long-term medical marijuana use and/or the combined effect of prescription opioid use in adults 50 and older who endorse chronic or severe non-malignant pain. Further, studies examining how older adults self-regulate prescription medication use and driving behavior is limited, with none rigorously examining medical marijuana.
Primary outcome measures
- Sum of Maneuvers Score (SMS) [Time frame: One Day]
Eligibility criteria
Inclusion criteria
- Age 50 and older who endorse chronic or severe non-malignant pain
- Resident of Florida with an active and valid Florida Drivers License
- Can communicate in English
- Willing and able to complete study procedures
- Have active medical marijuana card for >12 months issued by the state of Florida (MMG group) OR are race-sex match who has not used marijuana in the past 10 years with no history of daily use (NMG group)
Exclusion criteria
- Have active psychosis
- Have lost or revoked driving privileges
- Score of below the cut 24 (out of 30) on the Montreal Cognitive Assessment (MoCA)
- Are a control participant who urine test positive for marijuana use and/or reports any marijuana use in past 10 years
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 2 centers
- University of Florida — Gainesville
- Florida State University, Center for Translational Behavioral Science — Tallahassee
Publications
- Ennis N, Classen S. An Open-Road Driving Performance Task to Examine Long-Term Medical Marijuana Use and Prescription Opioid Positivity Among Adults Aged 50 Years and Older: Protocol for an Observational Trial. JMIR Res Protoc. 2025 Nov 28;14:e77944. doi: 10.2196/77944. PMID 41313623
Identifiers
NCT: NCT06995937 · STUDY00005560 · 1R01DA057965