Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Lipoprotein(a). Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Improved Assessment of Cardiovascular Risk Through Imaging in Relatives Identified By Lipoprotein(a) Cascade Screening
Overview
Lipoprotein(a), or Lp(a), is a type of cholesterol that can increase the risk of heart and blood vessel disease. Many people are unaware they have high Lp(a), since it is not routinely measured and usually causes no symptoms on its own. However, elevated Lp(a) levels tend to run in families, meaning that close relatives of individuals with high Lp(a) are more likely to have it as well. At Amsterdam UMC, family members of patients with high Lp(a) are invited for cascade screening, which includes testing for Lp(a) and other cardiovascular risk factors. From this screened group, a selection of individuals with either high or low Lp(a) levels are invited to participate in the IMAGE-LPA study. In IMAGE-LPA, participants undergo a comprehensive cardiovascular evaluation, including blood tests and heart imaging using CT scans. Two types of scans are performed: (1) a calcium score scan to detect early calcium buildup in the heart's arteries (an early marker of atherosclerosis), and (2) coronary CT angiography to assess for plaque and narrowing in the coronary arteries. The goal of the study is to compare individuals with high versus low Lp(a) identified through cascade screening, to determine whether high Lp(a) levels are associated with early signs of heart disease in this patient group. The study does not involve any medications or invasive procedures. The findings may help clarify whether heart imaging can improve early detection in individuals with high Lp(a), and guide future strategies for preventing cardiovascular disease in families affected by this inherited risk factor.
Primary outcome measures
- Number of Participants with Coronary Atherosclerotic Plaque Detected on CCTA [Time frame: Day 1]
Secondary outcome measures (8)
- Number of Participants with Obstructive Coronary Stenosis (≥50% Luminal Narrowing) on CCTA [Time frame: Day 1]
- Total Coronary Plaque Volume [Time frame: Day 1]
- Calcified and Non-Calcified Plaque Volumes [Time frame: Day 1]
- Low-Attenuation Plaque Volume [Time frame: Day 1]
- Pericoronary Adipose Tissue (PCAT) Attenuation [Time frame: Day 1]
- Number of High-Risk Plaque Features [Time frame: Day 1]
- Coronary Artery Calcium (CAC) Score [Time frame: Day 1]
- CAD-RADS Classification [Time frame: Day 1]
Eligibility criteria
In order to be eligible to participate in this study in the elevated Lp(a) subgroup, a subject must meet all of the following inclusion criteria:
- Man or woman ≥50 years of age;
- Lp(a) level ≥ 150 nmol/L;
- Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic;
- Able and willing to provide informed consent;
- Able to comply with study requirements.
In order to be eligible to participate in this study in the Low Lp(a) subgroup, a subject must meet all of the following inclusion criteria:
- Man or woman ≥50 years of age;
- Lp(a) level < 50 nmol/L;
- Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic;
- Able and willing to provide informed consent;
- Able to comply with study requirements.
A potential subject who meets any of the following criteria will be excluded from participation in this study (both subgroups):
- Renal insufficiency, defined as eGFR < 30 ml/min
- History of ASCVD (acute coronary syndrome, history of myocardial infarction, stable or unstable angina pectoris or coronary or other arterial revascularization, stroke, transient ischemic attack or peripheral artery disease including aortic aneurysm, all of atherosclerotic origin)
- History of atrial fibrillation
- Prior and current use of statins
- Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
- Unable or unwilling to provide informed consent
- Unable to comply with study requirements.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Netherlands · 1 center
- Amsterdam UMC — Amsterdam
Publications
- Annink ME, Janssen ES, Reeskamp LF. Effectiveness of cascade screening for elevated lipoprotein(a), an underdiagnosed family disorder. Curr Opin Lipidol. 2024 Dec 1;35(6):290-296. doi: 10.1097/MOL.0000000000000951. Epub 2024 Sep 18. PMID 39259684
Identifiers
NCT: NCT06995183 · 2024.1104