Risk Assessment of Mild Traumatic Brain Injury in Military Training
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Quantification of mild trauma brain injury risk, Biomechanical Analysis of Head Impact Forces.
- Who it may be relevant to
- Registry conditions: Trauma, Brain. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Czechia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Identification and Risk Assessment of Mild Traumatic Brain Injury (mTBI) in Czech Armed Forces Soldiers During Specific Training Activities
Overview
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures.
Detailed description
The SNIPER-TBI study aims to quantify the risk of mild traumatic brain injury (mTBI) in Czech Armed Forces soldiers during high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study combines diagnostic biomarker analysis (GFAP, UCH-L1) and experimental biomechanical measurements using wearable sensors and high-speed cameras. These data will provide critical insights into the forces exerted on the brain during training and help establish exposure limits to minimize long-term neurological impairment. The results will guide the development of protective strategies and enhance soldier readiness.
Interventions
- Diagnostic test Quantification of mild trauma brain injury risk
Measure the incidence and severity of mTBI among soldiers engaged in high-risk training activities. (e.g. parachute jumps, high-caliber firearms shooting, artillery fire, explosions). Concentration of brain injury biomarkers (GFAP, UCH-L1) in blood samples collected within 24 hours post-exposure - Other Biomechanical Analysis of Head Impact Forces
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) and pressure wave analysis during training activities.
Primary outcome measures
- Quantification of mTBI Risk 1 [Time frame: Up to 24 hours post-exposure]
- Quantification of mTBI Risk 2 [Time frame: Up to 24 hours post-exposure]
- Biomechanical Analysis of Head Impact Forces 1 [Time frame: Baseline]
- Biomechanical Analysis of Head Impact Forces 2 [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Age 18-50 years
- Active-duty military personnel
- Participating in designated high-risk training activities
Exclusion criteria
- History of significant brain injury
- Current neurological disorders
- Use of anticoagulant medications
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Czechia · 1 center
- Military University Hospital Prague — Prague
Identifiers
NCT: NCT06992570 · SNIPER-mTBI