Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Needling + NBUVB, Microneedling + NBUVB.
- Who it may be relevant to
- Registry conditions: Vitiligo, Non-segmental Vitiligo. Basic parameters: 15 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Puncture to Repigment: A Comparative Analysis Of Needling vs. Microneedling Along With NBUVB in Treatment of Non-Segmental Vitiligo
Overview
This randomized controlled trial aims to compare the efficacy of needling versus microneedling, both followed by narrowband UVB therapy, in achieving repigmentation in patients with localized stable non-segmental vitiligo.
Detailed description
The study will enroll 80 patients aged 15-60 years with localized stable vitiligo. Participants will be randomized into two groups: one receiving needling and the other microneedling, each followed by NBUVB therapy. The primary outcome is the percentage of repigmentation at 12 weeks, assessed through digital planimetry and standardized clinical photography. Secondary outcomes include adverse effects such as erythema, post-inflammatory hyperpigmentation, infection, and scarring.
Interventions
- Procedure Needling + NBUVB
Participants in this arm will undergo needling using a sterile 30G (4mm) needle to manually puncture and implant melanocytes from perilesional pigmented skin into depigmented lesions. The procedure will be performed once every four weeks for a total of six sessions. - Procedure Microneedling + NBUVB
Participants in this arm will undergo microneedling using a Dermapen device with 1.5 mm needles to create controlled micro-injuries in depigmented skin to enhance melanocyte migration and repigmentation. This procedure will be performed once every four weeks for six sessions.
Primary outcome measures
- Treatment efficacy [Time frame: 12 weeks]
Secondary outcome measures (1)
- Adverse effects [Time frame: 12 weeks]
Eligibility criteria
Inclusion criteria
- Both male and female
- Age 15-60 years
- Patients having vitiligo for more than 1 year
Exclusion criteria
- Patients with tendency of keloid formation or hypertrophic scarring
- Patients with any bleeding disorder, coagulation defect or using anti platelets
- Any local infection at the treatment site
- Patients who had received systemic therapy in last 6 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Pakistan · 1 center
- Khyber Teaching Hospital — Peshawar
Identifiers
NCT: NCT06991972 · 187/DME/KMC