Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Lacidofil, Placebo.
- Who it may be relevant to
- Registry conditions: Pneumonia, Probiotics, Diarrhea. Basic parameters: 19 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Effect of Probiotic Administration on the Incidence of Antibiotic-associated Diarrhea in Patients With Community-acquired Pneumonia
Overview
The study goal is to determine whether oral administration of a probiotic mixture can reduce the incidence of antibiotic-associated diarrhea in patients with community-acquired pneumonia.
Interventions
- Drug Lacidofil
1 capsule twice daily. - Drug Placebo
1 capsule twice daily.
Primary outcome measures
- Occurrence of antibiotic-associated diarrhea [Time frame: Within 14 days after the cessation of Lacidofil or placebo administration]
Secondary outcome measures (3)
- Occurrence of Clostridium difficile infection [Time frame: Within 14 days after the cessation of Lacidofil or placebo administration]
- Total length of hospitalization [Time frame: Within 14 days after the cessation of Lacidofil or placebo administration]
- Duration of antibiotic use [Time frame: Within 14 days after the cessation of Lacidofil or placebo administration]
Eligibility criteria
Inclusion criteria
- Adult patients aged 19 years or older admitted with a diagnosis of community-acquired pneumonia
- Patients eligible for oral medication administration (able to take oral or enteral feeding)
Exclusion criteria
- Sepsis patients
- Patients admitted to the intensive care unit (ICU) following endotracheal intubation
- Elderly patients aged 80 years or older
- Pregnant women
- Patients who have diarrhea at the time of admission
- Patients with a history of using probiotics within 3 months prior to admission
- Patients with a history of using laxatives within 1 week prior to admission
- Patients suspected of being in shock (mean arterial pressure < 65 mmHg) at the time of admission
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Prevention
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06990568 · 2025-01-010 · NHIMC-2024-CR-070