Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Official title

Maintenance Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Overview

Maintenance Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Detailed description

Patients enrolled will be randomized to either experimental arm or control arm. Patients in experimental arm will receive pegylated liposomal doxorubicin (PLD) 40mg/m2 every 4 weeks. Maintenance PLD could be administered up to a total of 12 cycles. Patients in control arm will receive active surveillance without treatment (treatment holiday).

Interventions

• Drug Pegylated liposomal doxorubicin
  pegylated liposomal doxorubicin 40mg / m2 every 4 weeks for a maximum of 12 cycles.

Primary outcome measures

• Progression-free survival from randomization [Time frame: Up to approximately 2 years]

Secondary outcome measures (7)

• Overall survival (OS) [Time frame: Up to approximately 2 years]
• Progression-free survival (PFS) [Time frame: Up to approximately 2 years]
• Time to next treatment (TTNT) [Time frame: Up to approximately 2 years]
• Objective response rate (ORR) [Time frame: Up to approximately 2 years]
• Frequency and severity of AE [Time frame: Up to approximately 2 years]
• Safety of interest: cardiac function as assessed by LVEF [Time frame: Up to approximately 2 years]
• Quality of Life Effects on patient-reported outcomes as assessed by EORTC QLQ C30 [Time frame: Up to approximately 2 years]

Eligibility criteria

Inclusion criteria

• A histologically confirmed advanced soft tissue sarcoma. Note that subtypes typically do not use chemotherapy as standard treatment are not allowed, such as alveolar soft part sarcoma, solitary fibrous tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma)
• Patients received first-line anthracycline-based treatment for a minimum of 4 cycles and a maximum of 8 cycles.
• The best response after first-line anthracycline-based treatment must be either a complete response, partial response, or stable disease as defined by RECIST 1.1.

The best response should be attributed solely to systemic treatment and not to local therapy. All the patients must have at least one measurable tumor based on RECIST 1.1 before initiating first-line anthracycline-based treatment.

• Patients must be randomized within 8 weeks of their last dose of anthracycline-based treatment
• Patients have a life expectancy ≥ 3 months
• Patients older than 18 years old.
• ECOG performance status of 0 to 1.
• Patients must have adequate organ function and marrow reserve measured within 7 days prior to randomization as defined below:

• Hemoglobin ≥ 9.0 g/dL;
• Absolute neutrophil count ≥ 1,500/mm3;
• Platelets ≥ 100,000/mm3;
• Total bilirubin ≤ 1.5 x upper normal limit;
• AST(SGOT)/ALT(SGPT) ≤ 2.5 x upper normal limit; for patients with liver metastases AST(SGOT)/ALT(SGPT) ≤ 5 x upper normal limit is allowed;
• Serum creatinine ≤ 1.5mg/dL or creatinine clearance ≥50ml/min;
• All women of childbearing potential must have a negative pregnancy test obtained within 72 hours before starting therapy.
• For male participants: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.
• Patients with reproductive potential must use effective contraception (hormone orbarrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months after the completion of therapy.
• Patients must be able to comply with study procedures and sign informed consent.

Exclusion criteria

• Known allergy history to PLD or other drugs of liposome-based formulation.
• LVEF < 50% at screening as determined by UCG or MUGA.
• Serious non-healing wound, ulcer, or bone fracture not related to underlying sarcoma.
• Major surgical procedure, open biopsy, significant traumatic injury, or radiotherapy within 21 days prior to randomization.
• Severe, uncontrolled medical conditions including severe liver disease, heart disease, uncontrolled diabetes or hypertension, or pulmonary disease.
• Psychiatric illness or social situation that would preclude study compliance.
• Women with pregnant or breast feeding (a urine pregnancy test must be performed on all female patients who are of childbearing potential before entering the study, and the result must be negative.
• Another previous malignancy diagnosed within the past 3 years. Patients with carcinoma in situ and stage I malignancy under active surveillance (no medical treatment needed) are allowed for enrollment.
• Active CNS metastasis defined by clinical symptoms, cerebral edema, steroid or anti- convulsant requirement, or progressive growth. Patients with a history of CNS metastasis or cord compression are allowed in the study if they have been treated and are clinically stable.
• Patients with active hepatitis B. However, patients with controlled hepatitis B under anti-viral agent are allowed.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Open label

Primary purpose

Treatment

Study locations

Taiwan · 7 centers

• Chang Gung Memorial Hospital — Kaohsiung City
• Kaohsiung Medical University Chung-Ho Memorial Hospital, — Kaohsiung City
• China Medical University Hospital — Taichung
• National Cheng Kung University Hospital — Tainan
• National Taiwan University Hospital — Taipei
• Taipei Veterans General Hospital — Taipei
• Tri-Service General Hospital — Taipei

Identifiers

NCT: NCT06981637 · T1725

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗