Menu
Recruiting NCT06979674

Study of ESG406 in Adults With Solid Tumors

Phase I Interventional Locally Advanced/Metastatic Solid Tumors

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: ESG406.
Who it may be relevant to
Registry conditions: Locally Advanced/Metastatic Solid Tumors. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

An Open-Label, Multiple Dose, Dose Escalation and Cohort Expansion Phase I Study to Investigate the Safety, Tolerability, Pharmacokinetics and Antitumor Activities of ESG406 in Subjects With Locally Advanced/Metastatic Solid Tumors

Overview

This study is an open-label, dose-escalation and cohort expansion Phase I study, aiming to evaluate the safety, tolerability, PK characteristics and preliminary efficacy of ESG406, and determine the MTD, RP2D and administration regimens of ESG406. The study includes the dose escalation study in Phase Ia and the cohort expansion study in Phase Ib.

Interventions

  • Drug ESG406
    Administered via intravenous (IV) infusion.

Primary outcome measures

  • Percentage of Participants Experiencing Any Treatment Emergent Adverse Events and Serious Treatment Emergent Adverse Events [Time frame: First dose date up to last dose plus 30 days]
Secondary outcome measures (6)
  • Objective Response Rate [Time frame: Up to approximately 36 months.]
  • Progression Free Survival [Time frame: Up to approximately 36 months.]
  • Cmax [Time frame: Up to approximately 36 months.]
  • AUC0-inf [Time frame: Up to approximately 36 months.]
  • T1/2 [Time frame: Up to approximately 36 months.]
  • Anti-drug Antibodies [Time frame: Up to approximately 36 months.]

Eligibility criteria

Inclusion criteria

  • Males and females aged 18 to 80 years.
  • Histologically or cytologically confirmed advanced or metastatic solid tumor(s) for which no effective standard therapy is available or tolerable.
  • At least one measurable lesion per RECIST v1.1.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • Life expectancy ≥12 weeks.
  • Adequate organ and bone marrow function.
  • Fertile men and women of childbearing potential must agree to use an effective method of birth control from providing signed consent and for 180 days after last investigational product administration. Women of childbearing potential include pre-menopausal women and women within the first 2 years of the onset of menopause.

Exclusion criteria

  • Use of any cancer therapy (chemotherapy or other systemic anti-cancer therapies, immunotherapy) within 4 weeks before the first investigational product administration.
  • Toxicities from prior anti-tumor therapy not recovering to ≤ Grade 1.
  • Had major surgery within 4 weeks before dosing, or will not have fully recovered from surgery; or has surgery planned during the time the subject is expected to participate in the study or within 4 weeks after the last dose of study drug administration.
  • Use of any investigational anti-cancer drug within 4 weeks or 5 half-lives before the first investigational product administration.
  • A history of thromboembolic or cerebrovascular events within 6 months prior to the first dose of the investigational drug.
  • History of (noninfectious) interstitial pneumonia (ILD)/noninfectious pneumonitis requiring steroid therapy and current ILD/noninfectious pneumonitis, or suspected ILD/noninfectious pneumonitis at screening.
  • Subjects with symptomatic or untreated CNS metastases, or those requiring ongoing treatment for CNS metastases.
  • Patients with Primary CNS malignancy, or patients with other malignancies within 3 years prior to the first dose.
  • Patients with uncontrollable systemic diseases.
  • Subjects with clinically significant cardiovascular disease.
  • Human Immunodeficiency Virus (HIV) infection.
  • Active hepatitis B or hepatitis C.
  • Have an allergic constitution, or to be allergic to any investigational drug or excipient ingredient.
  • Pregnant or lactating women.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

China · 3 centers
  • Chongqing University Cancer Hospital — Chongqing
  • The First Affiliated Hospital of Xi 'An Jiaotong University — Xi’an
  • The Second Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou

Identifiers

NCT: NCT06979674 · ESG406-101

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗