PET/MRI/EEG Imaging Study in Epilepsy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: FDG-PET/fMRI/EEG imaging.
- Who it may be relevant to
- Registry conditions: Epilepsy. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging
Overview
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
Interventions
- Radiation FDG-PET/fMRI/EEG imaging
Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.
Primary outcome measures
- Image analysis [Time frame: Image analysis to be performed after imaging sessions are complete.]
Eligibility criteria
Inclusion criteria
- Age 18 or older
Additional Inclusion Criteria for Subjects with Epilepsy:
- Diagnosed with epilepsy with abnormal interictal EEG
Exclusion criteria
- Contraindications to PET, MRI, or EEG imaging
- History of severe brain disease such as stroke and head trauma
- History of brain surgery
- History of type I or II diabetes mellitus
- Fasting plasma glucose level >200 mg/dL
- Employed under direct supervision of the PI conducting the research
Additional Exclusion Criteria for Healthy Subjects:
- Current use of drugs that modulate brain function
- Current or past history of major medical, neurological, or psychiatric conditions
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- Athinoula A. Martinos Center — Charlestown
Identifiers
NCT: NCT06974305 · 2022P000929