HIIT in Sedentary Obese Adults: Effects on Metabolic Risk, Body Composition, and FABP4
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise.
- Who it may be relevant to
- Registry conditions: High-Intensity Interval Training. Basic parameters: 20 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Cyprus
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Effect of High-Intensity Interval Training on Cardiometabolic Risk Factors, Body Composition, and Plasma FABP4 Levels in Sedentary Obese Adults.
Overview
It is aimed to investigate the responses of Fatty Acid Binding Protein 4 (FABP4), which has been discovered as a novel biomarker of obesity and metabolic diseases, to regular exercise training. The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.
Detailed description
Fatty acid binding proteins are intracellular proteins involved in the transport of fatty acids and are particularly associated with lipolytic activity. These proteins constitute a group of molecules that regulate intracellular lipid responses and are linked to metabolic and inflammatory pathways.
Studies have shown that FABP4 is associated with hypertension, insulin resistance, obesity, and stroke.
Inhibition of FABP4 synthesis has emerged as a promising strategy for the treatment of obesity-related conditions, particularly insulin resistance and diabetes, and it is emphasized that exercise models to suppress FABP4 should be further investigated.
The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.
Hypotheses:
H01: HIIT has no effect on cardiometabolic risk factors in sedentary obese adults.
H02: HIIT has no effect on body composition in sedentary obese adults. H03: HIIT has no effect on plasma FABP4 levels in sedentary obese adults.
Interventions
- Other Exercise
The exercises will be applied only to the intervention group for 12 weeks and will be progressively intensified every 4 weeks.
Primary outcome measures
- Fatty acid-bling protein 4 [Time frame: Baseline, week 6 and week 12]
- Complete Blood Count [Time frame: Baseline, week 6 and week 12]
- Hemoglobin A1c (HbA1c) [Time frame: Baseline, week 6 and week 12]
- Hematocrit (HCT) [Time frame: Baseline, week 6 and week 12]
- Low-Density Lipoprotein [Time frame: Baseline, week 6 and week 12]
- High-Density Lipoprotein [Time frame: Baseline, week 6 and week 12]
- Triglycerides [Time frame: Baseline, week 6 and week 12]
- Fasting Blood Glucose (FBG) [Time frame: Baseline, week 6 and week 12]
- Total Cholesterol [Time frame: Baseline, week 6 and week 12]
Secondary outcome measures (6)
- Physical Activity Level Assessment [Time frame: Baseline, week 6 and week 12]
- Physical activity level [Time frame: Baseline, week 6 and week 12]
- Assessment of Aerobic Capacity and Exercise Intensity - used to measure an individual's maximal oxygen uptake (VO2max) and determine the intensity of exercise [Time frame: Baseline, week 6 and week 12]
- Anthropometric Measurements [Time frame: Baseline, week 6 and week 12]
- Antropometric Measurement [Time frame: Baseline, week 6 and week 12]
- Antropometric Measurement [Time frame: Baseline, week 6 and week 12]
Eligibility criteria
Inclusion criteria
- Aged between 20 and 35 years,
- BMI between 30 and 35 kg/m²,
- Waist circumference of 90-100 cm for women, 105-110 cm for men,
- Sedentary lifestyle (<600 MET-min/week),
- Referred by a physician (with a statement confirming no contraindication to exercise)."
Exclusion criteria
- BMI > 35,
- Pregnancy,
- Cardiovascular Diseases: Individuals with serious cardiovascular issues, such as uncontrolled hypertension, heart failure, coronary artery disease, or a heart attack within the last 6 months, which could pose a risk during exercise.
- Respiratory Diseases: Individuals with chronic respiratory conditions, such as uncontrolled or severe asthma or COPD, who cannot tolerate exercise due to their condition.
- Neurological Disorders: Individuals with neurological issues that limit exercise capacity, such as Parkinson's disease, stroke, or multiple sclerosis.
- Musculoskeletal Issues: Individuals with chronic musculoskeletal problems, particularly knee or hip osteoarthritis, that may increase the risk of pain or injury during exercise.
- Metabolic or Endocrine Disorders: Individuals with uncontrolled metabolic issues, such as diabetes or thyroid disorders, that could cause blood sugar or hormonal fluctuations during exercise.
- Acute Infections or Illness: Individuals with acute infections, fever, or recently undergone surgical procedures.
- Any health condition that may prevent participation in exercise."
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Cyprus · 1 center
- Eastern Mediterranean University — Famagusta
Identifiers
NCT: NCT06973980 · YDIREL