Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Premature neonates with invasive infection caused by Bacillus cereus.
- Who it may be relevant to
- Registry conditions: Sepsis, Infections. Basic parameters: up to 143 Days · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death. "
Interventions
- Biological Premature neonates with invasive infection caused by Bacillus cereus
The whole genome sequencing of the bacterial strains was performed by using both Illumina and Nanopore technologies, allowing us to obatin high quality and complete circular genomes.
Primary outcome measures
- Mortality [Time frame: 28 days after birth]
Eligibility criteria
Inclusion criteria
- Premature newborn (i.e born before 37 last menstrual periods) with invasive infection caused by B. cereus (strains isolated from blood culture and cerebrsopinal fluid)
Exclusion criteria
- None
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 13 centers
- CHU NICE — Nice
- CHU lille — Lille
- AP-HM Marseille — Marseille
- CHU Nantes — Nantes
- CHU Nîmes — Nîmes
- AP-HP Hôpital Robert Debré — Paris
- Hôpital Antoine Béclère, AP-HP — Paris
- Hôpital Cochin — Paris
- … and 5 more centers
Identifiers
NCT: NCT06973174 · 25LaboBacterio01