Respiratory Virus Infections in Acute Heart Failure
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Heart Failure Syndrome. Basic parameters: from 19 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Respiratory Virus Infections in Hospitalized Patients With Acute Heart Failure Syndrome: A Prospective Multi-center Observational Study
Overview
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort. The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.
Primary outcome measures
- Respiratory virus PCR detection rate [Time frame: Within 3 days of admission]
Secondary outcome measures (5)
- Days of hospitalization [Time frame: From admission to discharge during index hospitalization (upto 30 days)]
- Rate of ICU care or ventilation [Time frame: From admission to discharge during index hospitalization (upto 30 days)]
- In hospital mortality [Time frame: From admission to discharge during index hospitalization (upto 30 days)]
- mortality [Time frame: 12 month]
- Rehospitalization [Time frame: 12month]
Eligibility criteria
Inclusion criteria
- Adult aged 19 years or older admitted to the cardiology department with acute heart failure
- NT-proBNP >300 pg/mL
- Clinician judgement of possible respiratory viral infection (fever >38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5 mg/dL)
- Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons
Exclusion criteria
- Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP >180mmHg or DBP >110mmHg), haemoglobin <7g/dL or AHF precipitated by medication non-adherence)
- If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
- If there is a clear other source of infection that can explain the fever
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
South Korea · 3 centers
- Seoul National University Bundang Hospital — Seongnam-si
- Samsung medical center — Seoul
- Seoul ST. Mary's Hospital — Seoul
Identifiers
NCT: NCT06967441 · SNUBH IRB NO: B-2412-941-302