Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Prone ventilation.
- Who it may be relevant to
- Registry conditions: ARDS (Moderate or Severe). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
Overview
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
Detailed description
Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.
Interventions
- Behavioral Prone ventilation
Cerebral Blood Flow Monitoring Before and After Prone Ventilation in Patients with ARDS.Cerebral blood flow,intracranial pressure,and systemic hemodynamic monitoring were performed at the following time points:before prone positioning(T0),1 hour after prone ventilation(T1),12 hours after prone ventilation(T2),1 hour after returning to the supine position(T3),and 7 days after returning to the supine position(T4).
Primary outcome measures
- Neuroimaging Studies [Time frame: From enrollment to 2 weeks after the end of treatment.]
- Biomarker Detection [Time frame: From enrollment to 2 weeks after the end of treatment.]
Secondary outcome measures (2)
- Incidence rate of delirium [Time frame: From enrollment to 2 weeks after the end of treatment.]
- Cognitive function [Time frame: From enrollment to 2 weeks after the end of treatment.]
Eligibility criteria
Inclusion criteria
- Age≥18 years
- Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂<150 mmHg,and requiring prone ventilation
- Expected duration of mechanical ventilation>48 hours
- Written informed consent obtained
Exclusion criteria
- Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension)
- Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics
- Life-threatening ARDS
- Patients who are unable to undergo neurological assessment
- Poor image quality or absence of images
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
China · 1 center
- Sichuan Provincial People's Hospital, — Chengdu
Identifiers
NCT: NCT06967285 · KY2025PD21