Test of Target Engagement of Ambiguity Aversion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention.
- Who it may be relevant to
- Registry conditions: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety. Basic parameters: 25 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement
Overview
The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.
Detailed description
In this trial, participants will be randomized to one of two single session interventions (SSI). They will complete a decision making task before and after the SSI to measure their behavioral and brain responses to ambiguity, all on the same day. They will also complete a brief measure of hopelessness before and after the SSI. The main analysis will compare changes in ambiguity aversion before and after the interventions. Participants will also be asked to complete questionnaires before completing the task and SSI. The questionnaires will be about the participant's emotions and symptoms of depression and anxiety, personality, and avoidance/tolerance of uncertainty.
Interventions
- Behavioral Uncertainty-focused single session intervention
Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60 - Behavioral Maintaining a healthy lifestyle single session intervention
Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60
Primary outcome measures
- Beck Hopelessness Scale-4 (BHS-4) [Time frame: 1 hour]
- Behavioral ambiguity aversion [Time frame: 1 hour]
- Event-related potential responses to ambiguous choices [Time frame: 1 hour]
Eligibility criteria
Inclusion criteria
- Ages 25 to 60
- Right-handed
- Ability to read and write English
- Capacity to provide informed consent
- Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)
Exclusion criteria
- Personal history of psychosis, mania, or hypomania
- Personal history of autism spectrum disorder
- IQ < 80 as determined by the Wechsler Test of Adult Reading
- Head injury with greater than 120 seconds loss of consciousness
- Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
- Currently pregnant
- Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Northwestern University — Chicago
Identifiers
NCT: NCT06962527 · K23MH136421