Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Colorectal Polyp, Colorectal Cancer Recurrent, Colorectal Adenoma. Basic parameters: 40 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.
Primary outcome measures
- The characteristics of the intestinal microbiota in patients with high-risk colorectal polyp recurrence [Time frame: 24 months]
Secondary outcome measures (1)
- Development and validation of Microbiota and metabolite-based model predicting recurrence of high-risk colorectal polyps after polypectomy [Time frame: 36 months]
Eligibility criteria
Inclusion criteria
- patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
Exclusion criteria
- patient with severe physical diseases that prevented them from adhering to the examination requirements,
- patient with coagulopathy or other contraindications for biopsy or polypectomy,
- patient with previous surgical procedures on the gastrointestinal tract,
- presence of colorectal cancer or other malignant tumor at baseline
- presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
- within 1 month before enrollment, oral antibiotics and probiotics were taken;
- inability to provide informed consent or refusal to participate in the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing, China — Beijing
Identifiers
NCT: NCT06957626 · I-23PJ699