REhabilitation of MEMory Symptoms After BRain Concussion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cognitive behavioral therapy, Cognitive rehabilitation.
- Who it may be relevant to
- Registry conditions: Concussion, Brain, Mild Traumatic Brain Injury. Basic parameters: 18 years — 59 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective memory functioning. The present study will more definitively compare the effectiveness of these interventions for improving subjective memory functioning after concussion.
Detailed description
The primary research aims of this study are to determine whether cognitive behavioral therapy (CBT) and cognitive compensatory strategy training (CCST) improves subjective memory functioning compared to usual care, and to compare the effectiveness of CBT and CCST. This study is a multisite three-armed randomized control trial (RCT) that will randomize adults with persistent memory symptoms following concussion to CBT, CCST, or a covert waitlist condition (2:2:1). Participants will be blinded to the other arms of the study and the study hypotheses.
Interventions
- Behavioral Cognitive behavioral therapy
Cognitive behavioral therapy (CBT) is delivered by a psychologist over 10 individual (1:1) manualized videoconference sessions. The goal of this therapy is for participants to use their memory more normally (i.e., reduce avoidance and safety behaviors) and view memory lapses as less threatening. - Behavioral Cognitive rehabilitation
Cognitive compensatory strategy training (CCST), a traditional cognitive rehabilitation intervention, is delivered by a Occupational Therapist over 10 individual (1:1) manualized videoconference sessions. Participants optimize their use of current compensatory strategies and/or learn new ones suited to their needs and lifestyle. The goal is to minimize memory lapses in daily life.
Primary outcome measures
- Multifactorial Memory Questionnaire-Satisfaction scale [Time frame: Week 20]
Secondary outcome measures (3)
- Fear-Avoidance of Memory Loss Scale [Time frame: Week 1 and week 20]
- Patient Global Impression of Change scale [Time frame: Week 20]
- Work and Social Adjustment Scale [Time frame: Week 1 and week 20]
Eligibility criteria
Inclusion criteria
- Age 18-59
- Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria
- Concussion occurred between 6 and 36 months before enrollment
- Ongoing memory concerns
- Fluent in English
- Stable access to a computer, tablet, or smartphone with internet capability
Exclusion criteria
- Fail performance validity testing
- Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
Canada · 8 centers
- Calgary Brain Injury Program — Calgary
- Fraser Health Acquired Brain Injury and Concussion Services — Langley
- G.F. Strong Adult Concussion Services — Vancouver
- Integrated Adult Concussion Program at Hamilton Health Sciences — Hamilton
- 360 Concussion Care Clinic — Ottawa
- Sunnybrook Traumatic Brain Injury Clinic — Toronto
- Hull-Ellis Concussion and Research Clinic at University Health Network — Toronto
- Canadian Concussion Centre at Toronto Western Hospital — Toronto
Publications
- Rioux M, Mamman R, Byworth MT, Panenka WJ, Howard AK, Perez DL, Schmidt J, Courchesne C, LeMoult J, Heran MK, Silverberg ND. Pilot feasibility randomised controlled trial of cognitive-behavioural therapy for functional cognitive disorder after concussion. BMJ Neurol Open. 2024 Oct 11;6(2):e000666. doi: 10.1136/bmjno-2024-000666. eCollection 2024. PMID 39410977
Identifiers
NCT: NCT06956417 · H24-02486