Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity.
- Who it may be relevant to
- Registry conditions: Dental Caries. Basic parameters: 8 years — 10 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Evaluation of the Salivary-free Amino Acids Levels With Caries Activity
Overview
This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the predictive capacity of caries susceptibility
Detailed description
80 healthy children (8-10 years old) will be recruited from primary schools of Baghdad city/ Iraq, will be classified according to their level of caries activity (high caries activity, n = 40; negative caries activity, n = 40). Total stimulated and unstimulated saliva will be collected to estimate the caries activity by using the Snyder test, and Amino acid analysis of the saliva will be performed by reversed phase - high performance liquid chromatography (RP-HPLC), respectively.
Interventions
- Diagnostic test To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity
The investigators will measure Salivary-free amino acids by using reverse phase high performance liquid chromatography
Primary outcome measures
- Salivary-free amino acid analysis [Time frame: Baseline :unstimulated saliva collection for salivary glycine , proline , lysine and alanine measurement]
Eligibility criteria
Inclusion criteria
- Children aged (8,9,10) years with different caries
- Absence of signs of gingivitis or periodontal disease.
Exclusion criteria
- Children out the range of age
- Children with any systemic discases.
- Children with appliances in the mouth.
- Children with appliances in the mouth.
- Children with antibiotic treatment or any other drug over the last two weeks. B
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06953557 · Mustansiriyah