Study on Multi-Modality Models of Cardiac Function in Healthy Individuals
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Multiple speed increments from 3km/h to 8km/h on a treadmill.
- Who it may be relevant to
- Registry conditions: Healthy Volunteers Only. Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Study on the 'Seismocardiography-Electrocardiography' Coupling Dynamics and Its Exercise-load Reactivity Model in Healthy Individuals
Overview
In this study, wearable multi-modal microsensors were deployed to simultaneously capture seismocardiography (SCG) and electrocardiography (ECG) signals, delineating the exercise-load-dependent responsiveness of SCG-ECG dynamic coupling during graded-speed treadmill protocols.
Detailed description
The heart adapts to varying exercise loads primarily by augmenting heart rate and contractility to achieve matching increases in cardiac output. However, whether there exists an intrinsic triaxial regulatory mechanism governing the interdependencies among 'exercise load - heart rate response - contractility response' remains unknown. In this study, participants performed treadmill exercise at multiple speed gradients (3-8 km/h). Seismocardiography (SCG) signals were captured via an inertial measurement unit (IMU) positioned on the precordium and were used to characterize mechanical cardiac contractility. Single-lead precordial ECG provided heart rate dynamics, while CPET-derived oxygen uptake (VO₂) indexed exercise intensity. The primary objectives were to delineate SCG-ECG responsivity patterns under graded exercise intensities and quantify potential intrinsic laws linking exercise load, heart rate adaptation, and contractility modulation.
Interventions
- Behavioral Multiple speed increments from 3km/h to 8km/h on a treadmill
Healthy participants will undergo a fixed experimental protocol of multi-stage treadmill speed walking/running wearing microsensors and a respiratory/metabolic testing mask.
Primary outcome measures
- Changes in Seismocardiography (SCG) Signal Amplitude (m/s²) [Time frame: The entire test will be completed in approximately 90 minutes.]
Secondary outcome measures (1)
- Changes in Electrocardiogram (ECG) R-R Intervals (ms) [Time frame: The entire test will be completed in approximately 90 minutes.]
Eligibility criteria
Inclusion criteria
- Age 18-60 years
- Healthy individuals with no significant medical history
- Signed informed consent as an acceptance to participate to the trial
Exclusion criteria
- History of severe cardiovascular, cerebrovascular, pulmonary, hepatic, renal, psychiatric, or other critical systemic disorders
- Peripheral vascular diseases, musculoskeletal disorders, or other conditions limiting physical mobility
- Uncontrolled hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg)
- History of anemia
- Moderate to severe obesity (BMI ≥32.5 kg/m²)
- Pregnant or lactating women
- Any other conditions deemed ineligible for participation per investigator's discretion
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
China · 1 center
- Building 16, Lane 775, Hangdong Road, Shanghai — Shanghai
Identifiers
NCT: NCT06952673 · RW-H-001